DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SecCl and Gabrd

DIOPT Version :9

Sequence 1:	NP_001261986.1	Gene:	SecCl / 39949	FlyBaseID:	FBgn0036727	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_058985.1	Gene:	Gabrd / 29689	RGDID:	61901	Length:	449	Species:	Rattus norvegicus

Alignment Length:	520	Identity:	130/520 - (25%)
Similarity:	223/520 - (42%)	Gaps:	108/520 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WITL-ILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRL----ERPFEYDSDG 70
            |:.| :|:|......|.:|       |.|.|....:.|  .::.:...|.|    .|.|.....|
  Rat     6 WLLLPLLLLCTQPHHGARA-------MNDIGDYVGSNL--EISWLPNLDGLMEGYARNFRPGIGG 61

  Fly    71 KRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILG-QKHLSERLWL 134
            .  |:.|...:.|..:.:::...:::.|...|...::|.||:|   |.::..|| .....::|||
  Rat    62 P--PVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSY---NHTNETLGLDSRFVDKLWL 121

  Fly   135 PHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWM 199
            |..|..|.:.:.......::.|..|.|:|.::.|.|:.:::.|.|:..|:|.|:|.|...|||:.
  Rat   122 PDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLESYG 186

  Fly   200 YNTSDLILEW-EPHTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNL 263
            |::.|::..| |....|.....::|.::.:..:...|.::     |.:.   ||.:..||....|
  Rat   187 YSSEDIVYYWSENQEQIHGLDRLQLAQFTITSYRFTTELM-----NFKS---AGQFPRLSLHFQL 243

  Fly   264 KREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIK 328
            :|..|.|::..|:||:::||:||||||:...|.|.|:.||.:|:|:..||..|...:||:.|.||
  Rat   244 RRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIK 308

  Fly   329 VSEVWFLGCTFFIFGSLVEFAFV--NTIWRRKENIELKKVNSK-------YIIKSTLTPRPARRQ 384
            ..:|:|..|..|:|.:|||:||.  |..:|:|...::|....:       .|:..:|:.....::
  Rat   309 ALDVYFWICYVFVFAALVEYAFAHFNADYRKKRKAKVKVTKPRAEMDVRNAIVLFSLSAAGVSQE 373

  Fly   385 IGGSLSNESRARSCSSLDNIVSSTESVR-----------NGNGTVNQGFNNYLTVHPNLPIIRTE 438
            :..| ..:.|...     |::.|..||.           .|.|.:..               |.:
  Rat   374 LAIS-RRQGRVPG-----NLMGSYRSVEVEAKKEGGSRPGGPGGIRS---------------RLK 417

  Fly   439 CAEADTVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYW 503
            ..:|||                                      ||..:|.:|||.|.|.|.:||
  Rat   418 PIDADT--------------------------------------IDIYARAVFPAAFAAVNIIYW 444

Fly 504 503
Rat 445 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	121/487 (25%)
		Neur_chan_LBD	44..267	CDD:280998	54/228 (24%)
		Neur_chan_memb	275..503	CDD:280999	63/247 (26%)
Gabrd	NP_058985.1	LGIC_ECD	63..246	CDD:355788	47/193 (24%)
Gabrd	NP_058985.1	LGIC_TM	249..>337	CDD:365787	38/87 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810