Protein Alignment SecCl and GLRB

DIOPT Version :9

• Sequence 1: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_000815.1
• Gene: GLRB / 2743
• HGNCID: 4329
• Length: 497
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 144/547 - (26%)
• Similarity: 249/547 - (45%)
• Gaps: 100/547 - (18%)

  Fly    10 FWIT--LILVLSIWTSVGVKAEEEE-----------CPSMADAGSLQQ------TQLIQRLTHVC 55
            |.:|  .::::|:|.......|:..           |||...|..|.:      :.::.||  :.
Human     3 FLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPANSTSNILNRL--LV 65

  Fly    56 RYDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKA-FNRS 119
            .||...||     :.|.:|:.|...|::....::....:.::::..|:.::.|.||...: |..|
Human    66 SYDPRIRP-----NFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGS 125

  Fly   120 DNILGQKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKF 184
            |.:.....:.:.||.|.:|||||:.::.....::::|..:..:|:|::|.|:..:|.|.::...|
Human   126 DALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLF 190

  Fly   185 PFDQQFCSTVLESWMYNTSDLILEWEPHTPI--------SFDPEMRLTEY-NMAQFWHNTTIVQS 240
            |.|.|.|...|||:.|.|.||...|:...|:        .||.:....|| |..:::..|
Human   191 PMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGT----- 250

  Fly   241 DGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTS 305
                       |.|:.:.....|:|::|||::..|.|:::||.:||:|||:..|||..|:.||..
Human   251 -----------GYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIF 304

  Fly   306 TMLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTIWRRKENIELKK----- 365
            ::||..:..::.:..||||||:|..:||.:.|..|.|.||||:|.|..:....:.:|.:|
Human   305 SVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAK 369

  Fly   366 ----------VNSKYIIKSTLTP-RPARRQIGGSLSNESRARS-CSSLDNIVSSTESVRNGNGTV 418
                      |..|..:..|.|| ..:..|:|     |:|.:. |:|..::.|:..|:   .|::
Human   370 AEQADGKGGNVAKKNTVNGTGTPVHISTLQVG-----ETRCKKVCTSKSDLRSNDFSI---VGSL 426

  Fly   419 NQGF--NNYLTVHPNLPIIRTECAEADTVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAM 481
            .:.|  :||            :|...      ....||.......|:.|..||....:  ...|.
Human   427 PRDFELSNY------------DCYGK------PIEVNNGLGKSQAKNNKKPPPAKPVI--PTAAK 471

  Fly   482 WIDRRSRFLFPAMFLAFNALYWTFVYV 508
            .||..:|.|||..||.||.:||: :|:
Human   472 RIDLYARALFPFCFLFFNVIYWS-IYL 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	133/496 (27%)
		Neur_chan_LBD	44..267	CDD:280998	56/238 (24%)
		Neur_chan_memb	275..503	CDD:280999	72/246 (29%)
GLRB	NP_000815.1	LIC	43..496	CDD:273305	135/504 (27%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	48/201 (24%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	247..253		2/21 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910