Protein Alignment SecCl and GLRA1

DIOPT Version :9

• Sequence 1: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_001139512.1
• Gene: GLRA1 / 2741
• HGNCID: 4326
• Length: 457
• Species: Homo sapiens
• Alignment Length: 506
• Identity: 139/506 - (27%)
• Similarity: 238/506 - (47%)
• Gaps: 87/506 - (17%)

  Fly    16 LVLSIWTSV---GVKAEEEECPSMADAGSLQQTQLIQRLT-HVCRYDRLERPFEYDSDGKRLPIV 76
            |.|.:|.::   .:.|.:|...:.:....:..:..:.:|. ....||...||     :.|..|:.
Human     7 LRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRP-----NFKGPPVN 66

  Fly    77 VKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHLSERLWLPHIFFAN 141
            |...|::....::....:.::::..|:.::.|.||||..: ..|::.....:.:.:|.|.:||||
Human    67 VSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEY-PDDSLDLDPSMLDSIWKPDLFFAN 130

  Fly   142 ERESSI--LGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNTSD 204
            |:.:..  :.||.|  |..:|..|||:.|.|:..:|.|.|:.:.||.|.|.|...|||:.|..:|
Human   131 EKGAHFHEITTDNK--LLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMND 193

  Fly   205 LILEWEPHTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGA---FAGNYSSLSFTVNLKRE 266
            ||.||:....:.....:.|.::          |::.:.| ||:..   ..|.::.:....:|:|:
Human   194 LIFEWQEQGAVQVADGLTLPQF----------ILKEEKD-LRYCTKHYNTGKFTCIEARFHLERQ 247

  Fly   267 IGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIKVSE 331
            :|:||:..|:||::||.:||:|||:..||:|.|:.||.:|:|:..|.||....:||||||:|..:
Human   248 MGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAID 312

  Fly   332 VWFLGCTFFIFGSLVEFAFVNTIWRR-KENIELKKVNSKYIIKSTLTPRPARRQIGGSLSNESRA 395
            :|...|..|:|.:|:|:|.||.:.|: ||.:..::                           .|.
Human   313 IWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRR---------------------------KRR 350

  Fly   396 RSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECAEA-DTVSICSARTNNDHIVD 459
            ...|.:.|:....|:   |.|..|  |:.| .:.|       .|.:| |.:|:..|..:|
Human   351 HHKSPMLNLFQEDEA---GEGRFN--FSAY-GMGP-------ACLQAKDGISVKGANNSN----- 397

  Fly   460 VDKDKKDTPPTFTTMTPQEI-------AMWIDRRSRFLFPAMFLAFNALYW 503
                 ...||...:.:|:|:       |..||:.||..||..||.||..||
Human   398 -----TTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYW 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	134/476 (28%)
		Neur_chan_LBD	44..267	CDD:280998	58/228 (25%)
		Neur_chan_memb	275..503	CDD:280999	71/236 (30%)
GLRA1	NP_001139512.1	LIC	7..446	CDD:273305	139/506 (27%)
		Strychnine-binding. /evidence=ECO:0000250|UniProtKB:O93430	230..235		1/4 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	391..410		4/28 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910