Protein Alignment SecCl and GABRR2

DIOPT Version :9

• Sequence 1: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_002034.3
• Gene: GABRR2 / 2570
• HGNCID: 4091
• Length: 465
• Species: Homo sapiens
• Alignment Length: 472
• Identity: 130/472 - (27%)
• Similarity: 220/472 - (46%)
• Gaps: 81/472 - (17%)

  Fly    49 QRLTHVCRYDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAY 113
            |:|..|..:|...||   ...|..:|:.|.  :.|..|.:::...:.|.|...|:..::|:|||:
Human    56 QQLLRVDEHDFSMRP---AFGGPAIPVGVD--VQVESLDSISEVDMDFTMTLYLRHYWKDERLAF 115

  Fly   114 -KAFNRSDNILGQKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYC 177
             .|.|:|....|:  |.:::|:|.:||.:.:.|....|...:::..:.|:|:|:.|.|:..:..|
Human   116 SSASNKSMTFDGR--LVKKIWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMC 178

  Fly   178 WMNFQKFPFDQQFCSTVLESWMYNTSDLILEWE-PHTPISFDPEMRLTEYNMAQFWHNTTIVQSD 241
            .|:|..||.|.|.||..|||:.|...||:|.|: ....:..|.::.|::: :.|.:|.|:
Human   179 NMDFSHFPLDSQTCSLELESYAYTDEDLMLYWKNGDESLKTDEKISLSQF-LIQKFHTTS----- 237

  Fly   242 GDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTST 306
              .|...:..|.|:.|.....|:|.|.|:||..|.|:.::|.:||||||:...|.|.|:.||.:|
Human   238 --RLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITT 300

  Fly   307 MLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVN---TIWRRKENIELKKVNS 368
            :|:..|:.:..:.::|:|||:|..:::......|:|.|::|:|.||   |:..|||    :|:..
Human   301 VLTMTTIITGVNASMPRVSYVKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKE----RKLRE 361

  Fly   369 KY------IIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLT 427
            |:      :...|:       .:.||.| ||.|.|.:........||..|.....|:.|.:.
Human   362 KFPCMCGMLHSKTM-------MLDGSYS-ESEANSLAGYPRSHILTEEERQDKIVVHLGLSG--- 415

  Fly   428 VHPNLPIIRTECAEADTVSICSART-----NNDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRS 487
                      |...|....:...:|     .|.|.                         ||:.|
Human   416 ----------EANAARKKGLLKGQTGFRIFQNTHA-------------------------IDKYS 445

  Fly   488 RFLFPAMFLAFNALYWT 504
            |.:|||.::.||.:||:
Human   446 RLIFPASYIFFNLIYWS 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	130/472 (28%)
		Neur_chan_LBD	44..267	CDD:280998	62/219 (28%)
		Neur_chan_memb	275..503	CDD:280999	62/241 (26%)
GABRR2	NP_002034.3	Neur_chan_LBD	51..464	CDD:332142	130/472 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810