Protein Alignment SecCl and GABRR1

DIOPT Version :9

• Sequence 1: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_002033.2
• Gene: GABRR1 / 2569
• HGNCID: 4090
• Length: 479
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 129/486 - (26%)
• Similarity: 238/486 - (48%)
• Gaps: 71/486 - (14%)

  Fly    28 AEEEECPSMADAGSLQQTQLI--QRLTHVCRYDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLN 90
            |.::..|.:..:..:.::.|.  ::|..:..:|...||   ...|..:|:.|.  :.|..|.:::
Human    53 AHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRP---GFGGPAIPVGVD--VQVESLDSIS 112

  Fly    91 SDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHLSERLWLPHIFFANERESSILGTDEKDV 155
            ...:.|.|...|:..::|:||::.:.|.. ::.....|.:::|:|.:||.:.:.|.|..|...:|
Human   113 EVDMDFTMTLYLRHYWKDERLSFPSTNNL-SMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNV 176

  Fly   156 LTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEWEP-HTPISFDP 219
            :..:.|:|.|:.|.|:..:..|.|:|.:||.|.|.||..:||:.|...||:|.|:. :..:..|.
Human   177 MLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDE 241

  Fly   220 EMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAI 284
            .:.|:::.:.:| |.||       .|...:..|.|:.|.....|:|.|.|:||..|.|:.::|.:
Human   242 RISLSQFLIQEF-HTTT-------KLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVML 298

  Fly   285 SWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFA 349
            ||||||:...|.|.|:.||.:|:|:..|:.:..:.::|:|||||..:::......|:|.|::|:|
Human   299 SWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYA 363

  Fly   350 FVN---TIWRRKENIELKKVNSKYIIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESV 411
            .||   |:..|||    :|:..|....|.|.| |....:.|:.|
Human   364 AVNYLTTVQERKE----QKLREKLPCTSGLPP-PRTAMLDGNYS--------------------- 402

  Fly   412 RNGNGTVNQGFNNYLTVH---PNLPIIRTECAEADTVSICSARTNNDHIVDVDKDKKDTPPTFTT 473
               :|.||. .:||:..:   |:..:::        :::.|.|::        ..:|....::.:
Human   403 ---DGEVND-LDNYMPENGEKPDRMMVQ--------LTLASERSS--------PQRKSQRSSYVS 447

  Fly   474 MTPQEIAMWIDRRSRFLFPAMFLAFNALYWT 504
            |.....|  ||:.||.:|||.::.||.:||:
Human   448 MRIDTHA--IDKYSRIIFPAAYILFNLIYWS 476

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	127/471 (27%)
		Neur_chan_LBD	44..267	CDD:280998	59/225 (26%)
		Neur_chan_memb	275..503	CDD:280999	62/233 (27%)
GABRR1	NP_002033.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	32..55		1/1 (100%)
		LIC	75..478	CDD:273305	126/464 (27%)
		Neur_chan_LBD	76..281	CDD:280998	58/218 (27%)
		Neur_chan_memb	288..475	CDD:280999	62/234 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810