Protein Alignment SecCl and GABRP

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_055026.1
• Gene: GABRP / 2568
• HGNCID: 4089
• Length: 440
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 127/522 - (24%)
• Similarity: 226/522 - (43%)
• Gaps: 108/522 - (20%)

  Fly     3 NLHLSEIFWITLILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRLERP-FEY 66
            :|||:       .:.||::|       |..|        :|.:|.   ...|.|.|:|..| ||.
Human     4 SLHLA-------FVCLSLFT-------ERMC--------IQGSQF---NVEVGRSDKLSLPGFEN 43

  Fly    67 DSDG--KRL-------PIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNI 122
            .:.|  |.|       |:.:...:.:..:.:::...:.:.....|:.|:.|:||.::. |:|..:
Human    44 LTAGYNKFLRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG-NKSFTL 107

  Fly   123 LGQKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFD 187
              ...|.|.||:|..:....::|.:......:.|..|...|.|:.:.|:..::.|.|:..|:|.|
Human   108 --DARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPMD 170

  Fly   188 QQFCSTVLESWMYNTSDLILEW-EPHTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFA 251
            .|.|...||||.|:.:|:...| ..:..:.....:||.:|.:.:::  |.:.:|..:       .
Human   171 TQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYF--TLVTRSQQE-------T 226

  Fly   252 GNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSS 316
            |||:.|.....|:|.:.:::|:.|:||..:|.:||||||:..|:.|.|..:|.:|:||..||...
Human   227 GNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTLMIG 291

  Fly   317 QSKNLPKVS-YIKVSEVWFLGCTFFIFGSLVEFAFVN-------TIWRRKENIELKKVNSKYIIK 373
            ...:||..: :||..:|:...|..|:||:|:|:|..:       ....|....|:::|:...||.
Human   292 SRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSITNIIN 356

  Fly   374 STLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTE 438
            |             |:|:..|..|.:|::   .|:::|...:.|:... :.:..|.
Human   357 S-------------SISSFKRKISFASIE---ISSDNVDYSDLTMKTS-DKFKFVF--------- 395

  Fly   439 CAEADTVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYW 503
                        |.....|||.          ||...|..    :|..|:.|||.:|:..|..||
Human   396 ------------REKMGRIVDY----------FTIQNPSN----VDHYSKLLFPLIFMLANVFYW 434

  Fly   504 TF 505
            .:
Human   435 AY 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	119/480 (25%)
GABRP	NP_055026.1	LIC	43..437	CDD:455710	110/458 (24%)
		LGIC_ECD	60..241	CDD:475126	43/192 (22%)