Protein Alignment SecCl and GABRG3

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_150092.2
• Gene: GABRG3 / 2567
• HGNCID: 4088
• Length: 467
• Species: Homo sapiens
• Alignment Length: 524
• Identity: 120/524 - (22%)
• Similarity: 221/524 - (42%)
• Gaps: 90/524 - (17%)

  Fly    14 LILVLSIWTSVGVKAEEEECPSMADAGSLQQ------------TQLIQRLTHVCRYDRLERPFEY 66
            |:|:|.:::.:..::.:.|.....|:.|.|:            |.::.:|..  .||:..||
Human     5 LLLLLCLFSGLHARSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNKLLR--EYDKKLRP--- 64

  Fly    67 DSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAY----KAFNRSDNILGQKH 127
              |....|.|:...|||..:..::|..:::::.......:.|.||.:    |....:.|::|
Human    65 --DIGIKPTVIDVDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKILTLNSNMVG--- 124

  Fly   128 LSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCS 192
               .:|:|...|.|.:.:........:.|..:..:|.::.:.|:..:..|.:....||.|:..|.
Human   125 ---LIWIPDTIFRNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCP 186

  Fly   193 TVLESWMYNTSDLILEWEPHTPISFDPE-MRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSS 256
            .:..|:.|...::|..|..::..:.|.: .||.:::.....:.|.||.:.         ||:|..
Human   187 LIFSSYGYPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVTTS---------AGDYVV 242

  Fly   257 LSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNL 321
            ::....|.|.:|::.:..|:|.::.|.:||||||::.||:|.|..||.:|:|:..|||:...|:|
Human   243 MTIYFELSRRMGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIARKSL 307

  Fly   322 PKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTIWRRKENIELKKVNSKYIIKSTLTPRPARRQIG 386
            |:|||:...:::...|..|:|.:|:|:|.:|.....::....||..|       |....:.|.|.
Human   308 PRVSYVTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTS-------LLHPDSSRWIP 365

  Fly   387 GSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECAEADTVSICSAR 451
            ..:|.::.: :.|.||.....|..:...|....|.|.:....         ||.
Human   366 ERISLQAPS-NYSLLDMRPPPTAMITLNNSVYWQEFEDTCVY---------ECL----------- 409

  Fly   452 TNNDHIVDVDKDKKDTPPTFTTMTPQEIAMW-----------IDRRSRFLFPAMFLAFNALYWT- 504
                       |.||....|......:...|           :|..||..||..||.||.:||.
Human   410 -----------DGKDCQSFFCCYEECKSGSWRKGRIHIDILELDSYSRVFFPTSFLLFNLVYWVG 463

  Fly   505 FVYV 508
            ::|:
Human   464 YLYL 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	113/490 (23%)
GABRG3	NP_150092.2	LIC	50..464	CDD:455710	111/474 (23%)
		LGIC_ECD_GABAAR_G	71..252	CDD:349801	37/195 (19%)
		Cys-loop	171..185	CDD:349801	4/13 (31%)