Protein Alignment SecCl and GABRG2

DIOPT Version :9

• Sequence 1: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_944493.2
• Gene: GABRG2 / 2566
• HGNCID: 4087
• Length: 515
• Species: Homo sapiens
• Alignment Length: 582
• Identity: 117/582 - (20%)
• Similarity: 215/582 - (36%)
• Gaps: 176/582 - (30%)

  Fly    11 WITLILVLSIWTSVGVKAEEEECPSMAD-----------AGSLQQTQLIQRLTHVCRYDRLERPF 64
            ||  :|:||::.....:..:::....|.           .|.:  |.::..|..  .||...||
Human    26 WI--LLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDV--TVILNNLLE--GYDNKLRP- 83

  Fly    65 EYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAY----KAFNRSDNILGQ 125
              |...|  |.::.|.:||..:..:|:..:::.:.......:.|:||.:    |....:.|::|
Human    84 --DIGVK--PTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVG- 143

  Fly   126 KHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQF 190
                 ::|:|..||.|.:::........:.:..:..:|.|:.:.|:.....|.:....||.|:..
Human   144 -----KIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHS 203

  Fly   191 CSTVLESWM----------------------------------------YNTSDLILEWE-PHTP 214
            |.....||.                                        |...:::.:|: ....
Human   204 CPLEFSSWSRSIAQAGMCSGVISAHYSLRFWGSTDPPTLASRVAGISDGYPREEIVYQWKRSSVE 268

  Fly   215 ISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSM 279
            :......||.:::.....:.|.:|::.         :|:|..:|...:|.|.:|::.:..|:|..
Human   269 VGDTRSWRLYQFSFVGLRNTTEVVKTT---------SGDYVVMSVYFDLSRRMGYFTIQTYIPCT 324

  Fly   280 MIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGS 344
            :||.:||||||:..||.|.|..||.:|:|:..|||:...|:||||||:...:::...|..|:|.:
Human   325 LIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSA 389

  Fly   345 LVEFA----FVNTIWRRKENIELKKVNSKYIIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIV 405
            |||:.    ||:.....|:. :.||.|
Human   390 LVEYGTLHYFVSNRKPSKDK-DKKKKN-------------------------------------- 415

  Fly   406 SSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECAEADTVSI----CSARTNN-DHIVDVDK--- 462
                                       |::|....:|.|:.|    .:.:.|| .|:.:.|:
Human   416 ---------------------------PLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYG 453

  Fly   463 ----DKKDTPPTFTTMTPQEIAMW-----------IDRRSRFLFPAMFLAFNALYW-TFVYV 508
                |.||....|..........|           :|..:|..||..|..||.:|| :::|:
Human   454 YECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	109/534 (20%)
		Neur_chan_LBD	44..267	CDD:280998	45/267 (17%)
		Neur_chan_memb	275..503	CDD:280999	61/254 (24%)
GABRG2	NP_944493.2	LIC	69..512	CDD:273305	108/530 (20%)
		Neur_chan_LBD	69..312	CDD:280998	44/264 (17%)
		Neur_chan_memb	319..509	CDD:280999	61/255 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810