Protein Alignment SecCl and GABRE

DIOPT Version :9

• Sequence 1: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_004952.2
• Gene: GABRE / 2564
• HGNCID: 4085
• Length: 506
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 120/531 - (22%)
• Similarity: 212/531 - (39%)
• Gaps: 139/531 - (26%)

  Fly    27 KAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNS 91
            |:.|.|..|.  .|.|.:...|.. |.:..||...||    ..|:: |.||...|.|..|..|:.
Human    55 KSTETETGSR--VGKLPEASRILN-TILSNYDHKLRP----GIGEK-PTVVTVEISVNSLGPLSI 111

  Fly    92 DLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHLSERLWLPHIFFANERESSILGTDEKDV- 155
            ..:::.:..:....:.|:||.|.  :..::::...::..:||:|..||.|.:.     |.|.::
Human   112 LDMEYTIDIIFSQTWYDERLCYN--DTFESLVLNGNVVSQLWIPDTFFRNSKR-----THEHEIT 169

  Fly   156 ----LTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEWEPHTPIS 216
                :..:..:|.|:.:.||.....|.::..:||.|...|.....|:.|..:::|.:||     :
Human   170 MPNQMVRIYKDGKVLYTIRMTIDAGCSLHMLRFPMDSHSCPLSFSSFSYPENEMIYKWE-----N 229

  Fly   217 FDPEM------RLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYY 275
            |..|:      :|.:::.....:.|.|:.:.         .|::..::...|:.|..|:.....|
Human   230 FKLEINEKNSWKLFQFDFTGVSNKTEIITTP---------VGDFMVMTIFFNVSRRFGYVAFQNY 285

  Fly   276 LPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFF 340
            :||.:...:||||||::.:::|.|..||.:::|:..||.:...||.|:||||...:.:...|..|
Human   286 VPSSVTTMLSWVSFWIKTESAPARTSLGITSVLTMTTLGTFSRKNFPRVSYITALDFYIAICFVF 350

  Fly   341 IFGSLVEFAFVNTIWRRKENIELKKVNSKYII----KSTLTPRPARRQIGGSLSNESRARS--CS 399
            .|.:|:|||.:|                 ::|    |:..:|:....:|.......:||||  |:
Human   351 CFCALLEFAVLN-----------------FLIYNQTKAHASPKLRHPRINSRAHARTRARSRACA 398

  Fly   400 SLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECAEADTVSICSARTNNDHIVDVDKDK 464
            .           ::....|.|             |:.||.::.:....|||:
Human   399 R-----------QHQEAFVCQ-------------IVTTEGSDGEERPSCSAQ------------- 426

  Fly   465 KDTPPT-------------------------FTTMTPQ-EIAMW-----------IDRRSRFLFP 492
              .||:                         :..|.|. |.:.|           :|..||.:||
Human   427 --QPPSPGSPEGPRSLCSKLACCEWCKRFKKYFCMVPDCEGSTWQQGRLCIHVYRLDNYSRVVFP 489

  Fly   493 AMFLAFNALYW 503
            ..|..||.|||
Human   490 VTFFFFNVLYW 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	114/515 (22%)
		Neur_chan_LBD	44..267	CDD:280998	48/233 (21%)
		Neur_chan_memb	275..503	CDD:280999	63/270 (23%)
GABRE	NP_004952.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..66		4/12 (33%)
		Neur_chan_LBD	71..276	CDD:280998	47/231 (20%)
		Neur_chan_memb	285..>408	CDD:280999	41/150 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	413..438		6/39 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810