Protein Alignment SecCl and GABRA5

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_000801.1
• Gene: GABRA5 / 2558
• HGNCID: 4079
• Length: 462
• Species: Homo sapiens
• Alignment Length: 461
• Identity: 117/461 - (25%)
• Similarity: 206/461 - (44%)
• Gaps: 89/461 - (19%)

  Fly    57 YDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRS-- 119
            ||...||    ..|:|: ..|:|.|||.....::...:::.:....:..::|:||.:|...:.
Human    60 YDNRLRP----GLGERI-TQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQRLP 119

  Fly   120 -DNILGQKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQK 183
             :|:|..|     :|.|..||.|.::|........:.|..|..:|.::.:.|:..|..|.|..:.
Human   120 LNNLLASK-----IWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPMQLED 179

  Fly   184 FPFDQQFCSTVLESWMYNTSDLILEW---EPHTPISFDPEMRLTEYN-MAQFWHNTTIVQSDGDN 244
            ||.|...|.....|:.|..|:::..|   ...:.:..:...||.:|: |.|......|..|.|:
Human   180 FPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTENISTSTGE- 243

  Fly   245 LRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLS 309
                     |:.::...:|||:||::::..|||.:|.|.:|.|||||..::.|.|.:.|.:|:|:
Human   244 ---------YTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLT 299

  Fly   310 FITLSSSQSKNLPKVSYIKVSEVWFLG-CTFFIFGSLVEFAFVNTI------WRRKENIELKKVN 367
            ..|||.|...:||||:|....: ||:. |..|:|.:|:|||.||..      |..|:.:|..|:.
Human   300 MTTLSISARNSLPKVAYATAMD-WFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKKALEAAKIK 363

  Fly   368 SKYIIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNL 432
            .|             |::   :.|:              ||.:...|.          ::..||:
Human   364 KK-------------REV---ILNK--------------STNAFTTGK----------MSHPPNI 388

  Fly   433 PIIRTECAEADTVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLA 497
            |..:|....::|.|:        .:...::...::..|:.:::.      ||:.||.:||.:|..
Human   389 PKEQTPAGTSNTTSV--------SVKPSEEKTSESKKTYNSISK------IDKMSRIVFPVLFGT 439

  Fly   498 FNALYW 503
            ||.:||
Human   440 FNLVYW 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	117/461 (25%)
GABRA5	NP_000801.1	LGIC_ECD_GABAAR_A5	58..256	CDD:349839	50/215 (23%)
		Cys-loop	173..187	CDD:349839	5/13 (38%)
		LGIC_TM_GABAAR_alpha	259..445	CDD:349854	62/240 (26%)
		TM1 helix	259..282	CDD:349854	10/22 (45%)
		TM2 helix	286..310	CDD:349854	9/23 (39%)
		TM3 helix	318..344	CDD:349854	11/26 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	377..412		7/52 (13%)
		TM4 helix	421..445	CDD:349854	9/29 (31%)