DRSC/TRiP Functional Genomics Resources

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Protein Alignment SecCl and GABRA4

DIOPT Version :10

Sequence 1:NP_648984.2 Gene:SecCl / 39949 FlyBaseID:FBgn0036727 Length:509 Species:Drosophila melanogaster
Sequence 2:NP_000800.2 Gene:GABRA4 / 2557 HGNCID:4078 Length:554 Species:Homo sapiens


Alignment Length:566 Identity:140/566 - (24%)
Similarity:228/566 - (40%) Gaps:118/566 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 LILVLSIWTSVGVKAEEEE-CPSMADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSDGKRLPIV- 76
            |.|.:.:..|.|...:||: |..       ..|:::..|  :..||...||      |...|:. 
Human    24 LCLAVCLNESPGQNQKEEKLCTE-------NFTRILDSL--LDGYDNRLRP------GFGGPVTE 73

  Fly    77 VKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKA---FNRSDNILGQKHLSERLWLPHIF 138
            |||.|||.....::...:::.|....:..:.||||.|..   ..|.:|::..|     :|.|..|
Human    74 VKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTK-----VWTPDTF 133

  Fly   139 FANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNTS 203
            |.|.::|........:.|..:...|.::.:.|:..|..|.|....||.|...|.....|:.|..|
Human   134 FRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKS 198

  Fly   204 DLILEWE--PHTPISFDPE-MRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKR 265
            ::|..|.  |...:....| ..|.:|::.....::..::|         ..|.|..::...:|:|
Human   199 EMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKS---------ITGEYIVMTVYFHLRR 254

  Fly   266 EIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIKVS 330
            ::|::::..|:|.:|.|.:|.||||:..::.|.|.:.|.:|:|:..|||.|...:||||||....
Human   255 KMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAM 319

  Fly   331 EVWFLG-CTFFIFGSLVEFAFVNTIWRRKENIELKKVNSKYIIKSTLTPRP-------------- 380
            : ||:. |..|:|.:|:|||.||..    .||:::|...|       |.:|              
Human   320 D-WFIAVCFAFVFSALIEFAAVNYF----TNIQMEKAKRK-------TSKPPQEVPAAPVQREKH 372

  Fly   381 -------------ARRQIGGSLSNESRARSCSSLDNIVSSTESV--RNGNGTVNQGFNNYLTVHP 430
                         .|::....:.:||...:.:.:.|..|.:.:|  .:..||.    .:||...|
Human   373 PEAPLQNTNANLNMRKRTNALVHSESDVGNRTEVGNHSSKSSTVVQESSKGTP----RSYLASSP 433

  Fly   431 NLPIIRTECAEA-------DTVSICSART------------NNDHI--------------VDVDK 462
            | |..|...||.       .:.|..|.||            :..|:              :....
Human   434 N-PFSRANAAETISAARALPSASPTSIRTGYMPRKASVGSASTRHVFGSRLQRIKTTVNTIGATG 497

  Fly   463 DKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYWTFVYV 508
            ....|||.............||:.:|.|||..|.|||.:||. ||:
Human   498 KLSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWV-VYL 542

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SecClNP_648984.2 LIC 43..505 CDD:455710 131/531 (25%)
GABRA4NP_000800.2 LIC 13..541 CDD:455710 138/563 (25%)
LGIC_ECD_GABAAR_A4 57..255 CDD:349838 50/217 (23%)
Cys-loop 172..186 CDD:349838 5/13 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..381 4/37 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..435 11/42 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 452..471 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 495..515 3/19 (16%)

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