Protein Alignment SecCl and GABRA3

DIOPT Version :9

• Sequence 1: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_000799.1
• Gene: GABRA3 / 2556
• HGNCID: 4077
• Length: 492
• Species: Homo sapiens
• Alignment Length: 474
• Identity: 126/474 - (26%)
• Similarity: 211/474 - (44%)
• Gaps: 74/474 - (15%)

  Fly    45 TQLIQRLTHVCRYDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDK 109
            |:::.||  :..||...||...|:..:     |||.|||.....::...:::.:....:..:.|:
Human    68 TRILDRL--LDGYDNRLRPGLGDAVTE-----VKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDE 125

  Fly   110 RLAYKAFNRSDNILGQKH-LSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQA 173
            ||   .|:....||...: |:.::|.|..||.|.::|........:.|..|...|.::.:.|:..
Human   126 RL---KFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTI 187

  Fly   174 SLYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEW----EPHTPISFDPEMRLTEYNMAQFWHN 234
            ...|.|:.:.||.|...|.....|:.|.|::::..|    .....::.|.. ||.:|::......
Human   188 HAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQDGS-RLNQYDLLGHVVG 251

  Fly   235 TTIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPR 299
            |.|::|.         .|.|..::...:|||:||::::..|||.:|.|.:|.|||||..::.|.|
Human   252 TEIIRSS---------TGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPAR 307

  Fly   300 IMLGTSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLG-CTFFIFGSLVEFAFVNTIWRRKENIEL 363
            .:.|.:|:|:..|||.|...:||||:|....: ||:. |..|:|.:|:|||.||...:|....|.
Human   308 TVFGVTTVLTMTTLSISARNSLPKVAYATAMD-WFIAVCYAFVFSALIEFATVNYFTKRSWAWEG 371

  Fly   364 KKVNSKYIIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTV 428
            |||.....:|......||::              .|:..|||.:|
Human   372 KKVPEALEMKKKTPAAPAKK--------------TSTTFNIVGTT-------------------- 402

  Fly   429 HPNLPIIRTECAEADTVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMW-----IDRRSR 488
               .||...:..|..|:|..:|.:.:.....:...|    .|:...:|.|...:     :|:.||
Human   403 ---YPINLAKDTEFSTISKGAAPSASSTPTIIASPK----ATYVQDSPTETKTYNSVSKVDKISR 460

  Fly   489 FLFPAMFLAFNALYW-TFV 506
            .:||.:|..||.:|| |:|
Human   461 IIFPVLFAIFNLVYWATYV 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	124/471 (26%)
		Neur_chan_LBD	44..267	CDD:280998	53/226 (23%)
		Neur_chan_memb	275..503	CDD:280999	67/233 (29%)
GABRA3	NP_000799.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	28..54
		LIC	69..478	CDD:273305	123/470 (26%)
		LGIC_ECD_GABAAR_A3	75..274	CDD:349837	49/216 (23%)
		Cys-loop	191..205	CDD:349837	5/13 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810