DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SecCl and GABRA2

DIOPT Version :9

Sequence 1:	NP_001261986.1	Gene:	SecCl / 39949	FlyBaseID:	FBgn0036727	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_001317619.1	Gene:	GABRA2 / 2555	HGNCID:	4076	Length:	511	Species:	Homo sapiens

Alignment Length:	534	Identity:	138/534 - (25%)
Similarity:	230/534 - (43%)	Gaps:	93/534 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTHVCR--------YDRLERPFEYDSDG 70
            |:.|..:|.           |:.....::|:.:....:|...|        ||...||...||..
Human    13 LLFVFLVWD-----------PARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSIT 66

  Fly    71 KRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHL-SERLWL 134
            :     |.|.|||.....::...:::.:....:.:::|:||.:|.   ..|||...:| :.::|.
Human    67 E-----VFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKG---PMNILRLNNLMASKIWT 123

  Fly   135 PHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWM 199
            |..||.|.::|........:.|..:..:|.::.:.|:.....|.|:.:.||.|...|.....|:.
Human   124 PDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYA 188

  Fly   200 YNTSDLILEW--EPHTPISFDPE-MRLTEYN-MAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFT 260
            |.||::...|  .....:...|: .||.:|: :.|.....||..|.|:          |:.::..
Human   189 YTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGE----------YTVMTAH 243

  Fly   261 VNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVS 325
            .:|||:||::::..|||.:|.|.:|.|||||..::.|.|.:.|.:|:|:..|||.|...:||||:
Human   244 FHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVA 308

  Fly   326 YIKVSEVWFLG-CTFFIFGSLVEFAFVNTIWRRKENIELKK-VNSKY-IIKS---TLTPRPARRQ 384
            |....: ||:. |..|:|.:|:|||.||...:|....:.|. ||.|. .||:   |||....:..
Human   309 YATAMD-WFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKSPSIKAEGITLTYNSVKAI 372

  Fly   385 IGG--------------SLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTV----HPN 431
            :.|              ||..|..........:.::..:|.:....:|....|.|...    .||
Human   373 LQGAKLIWSKYIAFSWPSLFQEKTLEYLEKWMDCLTFKQSSKKEKASVMIQNNAYAVAVANYAPN 437

  Fly   432 L---PIIRTECAEADTVSICSARTNNDHIVDVDKDKKDTP----PTFTTMTPQEIAMWIDRRSRF 489
            |   |::.|....|.|             .:.:|..::.|    .||.:::.      |||.||.
Human   438 LSKDPVLSTISKSATT-------------PEPNKKPENKPAEAKKTFNSVSK------IDRMSRI 483

  Fly   490 LFPAMFLAFNALYW 503
            :||.:|..||.:||
Human   484 VFPVLFGTFNLVYW 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	134/505 (27%)
		Neur_chan_LBD	44..267	CDD:280998	54/235 (23%)
		Neur_chan_memb	275..503	CDD:280999	75/258 (29%)
GABRA2	NP_001317619.1	LIC	25..500	CDD:273305	134/511 (26%)
GABRA2	NP_001317619.1	LGIC_ECD_GABAAR_A2	47..249	CDD:349836	51/219 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910