DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SecCl and GABRA1

DIOPT Version :9

Sequence 1:	NP_001261986.1	Gene:	SecCl / 39949	FlyBaseID:	FBgn0036727	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_000797.2	Gene:	GABRA1 / 2554	HGNCID:	4075	Length:	456	Species:	Homo sapiens

Alignment Length:	520	Identity:	139/520 - (26%)
Similarity:	225/520 - (43%)	Gaps:	109/520 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LSEIFWITLILVLSIWT--SVGVKAEEEECPSMADA---GSLQQTQLIQRLTHVCRYDRLERPFE 65
            ||:..| ..||:||..|  |.|.       ||:.|.   .:...|:::.||  :..||...||
Human     7 LSDCLW-AWILLLSTLTGRSYGQ-------PSLQDELKDNTTVFTRILDRL--LDGYDNRLRP-- 59

  Fly    66 YDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYK---AFNRSDNILGQKH 127
              ..|:|: ..|||.|:|.....::...:::.:....:..::|:||.:|   ...|.:|::..|
Human    60 --GLGERV-TEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK- 120

  Fly   128 LSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCS 192
                :|.|..||.|.::|........:.|..::.:|.::.:.|:.....|.|:.:.||.|...|.
Human   121 ----IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACP 181

  Fly   193 TVLESWMYNTSDLILEW--EP-HTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNY 254
            ....|:.|..::::.||  || .:.:..:...||.:|::.....::.||||.         .|.|
Human   182 LKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSS---------TGEY 237

  Fly   255 SSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSK 319
            ..::...:|||:||::::..|||.:|.|.:|.|||||..::.|.|.:.|.:|:|:..|||.|...
Human   238 VVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARN 302

  Fly   320 NLPKVSYIKVSEVWFLG-CTFFIFGSLVEFAFVNTI------WRRKENI--ELKKVNSKYIIKST 375
            :||||:|....: ||:. |..|:|.:|:|||.||..      |..|..:  :.|||... :||..
Human   303 SLPKVAYATAMD-WFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP-LIKKN 365

  Fly   376 LTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECA 440
            .|..|.......:|     ||....|..|..|.                  |:.|.
Human   366 NTYAPTATSYTPNL-----ARGDPGLATIAKSA------------------TIEPK--------- 398

  Fly   441 EADTVSICSARTNNDHIVDVDKDKKDTPP--TFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYW 503
                              :|..:.|...|  ||.:::.      |||.||..||.:|..||.:||
Human   399 ------------------EVKPETKPPEPKKTFNSVSK------IDRLSRIAFPLLFGIFNLVYW 439

Fly 504 503
Human 440 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	126/478 (26%)
		Neur_chan_LBD	44..267	CDD:280998	54/228 (24%)
		Neur_chan_memb	275..503	CDD:280999	68/238 (29%)
GABRA1	NP_000797.2	LIC	14..442	CDD:273305	136/512 (27%)
GABRA1	NP_000797.2	LGIC_ECD_GABAAR_A1	56..249	CDD:349835	48/211 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810