Protein Alignment SecCl and Glrb

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_445748.1
• Gene: Glrb / 25456
• RGDID: 2706
• Length: 496
• Species: Rattus norvegicus
• Alignment Length: 526
• Identity: 143/526 - (27%)
• Similarity: 239/526 - (45%)
• Gaps: 106/526 - (20%)

  Fly    27 KAEEEECPSMADAGSLQQ------TQLIQRLTHVCRYDRLERPFEYDSDGKRLPIVVKTRIYVYF 85
            |.::..|||...|..|.:      :.::.||  :..||...||     :.|.:|:.|...|::..
  Rat    33 KKKQYLCPSQQSAEDLARVPPNSTSNILNRL--LVSYDPRIRP-----NFKGIPVDVVVNIFINS 90

  Fly    86 LQNLNSDLLQFKMHALLQLRFQDKRLAYKA-FNRSDNILGQKHLSERLWLPHIFFANERESSILG 149
            ..::....:.::::..|:.::.|.||...: |..||.:.....:.:.||.|.:|||||:.::...
  Rat    91 FGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHD 155

  Fly   150 TDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEWEPHTP 214
            ..::::|..:..:|:|::|.|:..:|.|.::...||.|.|.|...|||:.|.|.||...|:...|
  Rat   156 VTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDP 220

  Fly   215 I--------SFDPEMRLTEY-NMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFY 270
            :        .||.:....|| |..:::..|                |.|:.:.....|:|::|||
  Rat   221 VQLEKIALPQFDIKKEDIEYGNCTKYYKGT----------------GYYTCVEVIFTLRRQVGFY 269

  Fly   271 LLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIKVSEVWFL 335
            ::..|.|:::||.:||:|||:..|||..|:.||..::||..:..::.:..||||||:|..:||.:
  Rat   270 MMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLI 334

  Fly   336 GCTFFIFGSLVEFAFVNTIWRRKENIELKKVNSKYIIKSTLTPRPARRQIGGSLSNESRARSCSS 400
            .|..|.|.||||:|.|..:....:.:|.:|..   |.|:        .|..|...|.::
  Rat   335 ACLLFGFASLVEYAVVQVMLNNPKRVEAEKAR---IAKA--------EQADGKGGNAAK------ 382

  Fly   401 LDNIVSSTESVRNGNGTVNQGFNNYLTVH-PNLPIIRTECAEADTVSICSARTNNDHIV------ 458
                    ::..||.||         .|| ..|.:..|.|.:..| |....|:|:..||
  Rat   383 --------KNTVNGTGT---------PVHISTLQVGETRCKKVCT-SKSDLRSNDFSIVGSLPRD 429

  Fly   459 -------------DVD--------KDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALY 502
                         :|:        |:||  ||....:.| ..|..||..:|.|||..||.||.:|
  Rat   430 FELSNYDCYGKPIEVNNGLGKPQAKNKK--PPPAKPVIP-TAAKRIDLYARALFPFCFLFFNVIY 491

  Fly   503 WTFVYV 508
            |: :|:
  Rat   492 WS-IYL 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	136/505 (27%)
Glrb	NP_445748.1	LIC	43..495	CDD:455710	138/513 (27%)
		LGIC_ECD_GlyR_beta	79..265	CDD:349811	48/201 (24%)
		Cys-loop	183..197	CDD:349811	5/13 (38%)