Protein Alignment SecCl and GABRR3

DIOPT Version :9

• Sequence 1: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_001099050.1
• Gene: GABRR3 / 200959
• HGNCID: 17969
• Length: 467
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 138/525 - (26%)
• Similarity: 246/525 - (46%)
• Gaps: 76/525 - (14%)

  Fly     1 MMNLHLSEIFWITLILVLSIWTSVGVKAEEEECPSMADAGSLQQT------------QLIQRLTH 53
            ::...|....:|.:||..::..:..:|...:.|.|.......|:|            |..::|.|
Human     2 VLAFQLVSFTYIWIILKPNVCAASNIKMTHQRCSSSMKQTCKQETRMKKDDSTKARPQKYEQLLH 66

  Fly    54 VCRYDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNR 118
            :...|...||....|     |:.|...::|..:.:::...:.|.|...|:..::|:||::.: ..
Human    67 IEDNDFAMRPGFGGS-----PVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPS-TA 125

  Fly   119 SDNILGQKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQK 183
            :.::.....|:.::|:|.|||.:.:.|.|..|..::::..:.|:|||::|.|:..|..|:|:|.:
Human   126 NKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSR 190

  Fly   184 FPFDQQFCSTVLESWMYNTSDLILEWEPHTPISFDPE--MRLTEYNMAQFWHNTTIVQSDGDNLR 246
            ||.|.|.||..|||:.||..||:|.|: |...|.:.|  |.|:::.:..|        |....|.
Human   191 FPLDTQNCSLELESYAYNEDDLMLYWK-HGNKSLNTEEHMSLSQFFIEDF--------SASSGLA 246

  Fly   247 HGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFI 311
            ..:..|.|:.|.....|:|.:.|::|..|.|::::|.:||||||:...|.|.|:.||.:|:|:..
Human   247 FYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTMS 311

  Fly   312 TLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVN---TIWRRKENIELKKVNSKYIIK 373
            |:.::.|.::|:|||:|..:|:....:.|:|.|::|:|.||   |:..||:..:..|::..|.|.
Human   312 TIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKISRMYNID 376

  Fly   374 STLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTE 438
            :.     ......|...:.......:||.  ::|.:.:|.
Human   377 AV-----QAMAFDGCYHDSEIDMDQTSLS--LNSEDFMRR------------------------- 409

  Fly   439 CAEADTVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYW 503
                  .||||..|::..|    |.:|........:..:...: ||..||.|||.:::.||..||
Human   410 ------KSICSPSTDSSRI----KRRKSLGGHVGRIILENNHV-IDTYSRILFPIVYILFNLFYW 463

  Fly   504 TFVYV 508
            . |||
Human   464 G-VYV 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	128/478 (27%)
		Neur_chan_LBD	44..267	CDD:280998	64/236 (27%)
		Neur_chan_memb	275..503	CDD:280999	59/230 (26%)
GABRR3	NP_001099050.1	LIC	55..466	CDD:273305	126/469 (27%)
		Neur_chan_LBD	59..267	CDD:280998	63/222 (28%)
		Neur_chan_memb	274..463	CDD:280999	59/231 (26%)
		Interaction with SQSTM1. /evidence=ECO:0000250	347..448		25/143 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810