Protein Alignment SecCl and Gabrr3

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_620252.1
• Gene: Gabrr3 / 192258
• RGDID: 621564
• Length: 464
• Species: Rattus norvegicus
• Alignment Length: 524
• Identity: 138/524 - (26%)
• Similarity: 246/524 - (46%)
• Gaps: 99/524 - (18%)

  Fly    11 WITLILVLSIWTSVGVKAEEEECPSMADAGSLQQTQL------------IQRLTHVCRYDRLERP 63
            ||||:|..|     .||...::|.|......:::|::            .::|.|:..:|...||
  Rat    14 WITLMLDAS-----AVKEPHQQCLSSPKQTRIRETRMRKDDLTKVWPLKREQLLHIEDHDFSTRP 73

  Fly    64 FEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHL 128
            ....|     |:.|...:.|..:.:::...:.|.|...|:..::|:||::.: ..:.::...:.|
  Rat    74 GFGGS-----PVPVGIDVQVESIDSISEVNMDFTMTFYLRHYWKDERLSFPS-TTNKSMTFDRRL 132

  Fly   129 SERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCST 193
            .:::|:|.|||.:.:.|.|..|..::::..:.|:|||:.|.|:..|..|:|:|.:||.|.|.||.
  Rat   133 IQKIWVPDIFFVHSKRSFIHDTTVENIMLRVHPDGNVLFSLRITVSAMCFMDFSRFPLDTQNCSL 197

  Fly   194 VLESWMYNTSDLILEWEPHTPISFDPE--MRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSS 256
            .|||:.||..||:|.|: |...|.:.|  :.|:::.:.:|        |....|...:..|.|..
  Rat   198 ELESYAYNEEDLMLYWK-HGNKSLNTEEHISLSQFFIEEF--------SASSGLAFYSSTGWYYR 253

  Fly   257 LSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNL 321
            |.....|:|.|.|::|..|.|:|::|.:||||||:...|.|.|:.||.:|:|:..|:.:..|.::
  Rat   254 LFINFVLRRHIFFFVLQTYFPAMLMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIVTGVSASM 318

  Fly   322 PKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTIWRRKENIELKKVNSKYIIKSTLTPRPARRQIG 386
            |:|||:|..:|:....:.|:|.|::|:|.||.:...:|..:|.:                |.:|.
  Rat   319 PQVSYVKAVDVYMWVSSLFVFLSVIEYAAVNYLTTVEEWKQLNR----------------RGKIS 367

  Fly   387 GSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTE-----CAEADTVS 446
            |..:.:  |....:.|.      ...:|...|:|   ....:|.....:||:     ||::..:.
  Rat   368 GMYNID--AVQAMAFDG------CYHDGETDVDQ---TSFFLHSEEDSMRTKFTGSPCADSSQIK 421

  Fly   447 ICSARTN-------NDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYWT 504
            ..|...|       |:|::|          |:               ||.:||.:::.||..||.
  Rat   422 RKSLGGNVGRIILENNHVID----------TY---------------SRIVFPVVYIIFNLFYWG 461

  Fly   505 FVYV 508
             :||
  Rat   462 -IYV 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	126/487 (26%)
Gabrr3	NP_620252.1	LIC	58..463	CDD:455710	125/472 (26%)
		LGIC_ECD	79..264	CDD:475126	55/194 (28%)
		Interaction with SQSTM1. /evidence=ECO:0000269|PubMed:12431995	344..445		25/152 (16%)