DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SecCl and lgc-42

DIOPT Version :9

Sequence 1:	NP_001261986.1	Gene:	SecCl / 39949	FlyBaseID:	FBgn0036727	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_497489.3	Gene:	lgc-42 / 189722	WormBaseID:	WBGene00021437	Length:	412	Species:	Caenorhabditis elegans

Alignment Length:	464	Identity:	120/464 - (25%)
Similarity:	201/464 - (43%)	Gaps:	107/464 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 ERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNIL-G 124
            ::|...:.:.| .|:.|....||..|.|..:..:.:.|...|.:.:||..:.:   |.::::| .
Worm    28 DKPMPRNGNPK-APLQVHFGFYVESLGNFRATEMTYDMDMYLYMSWQDDSMRH---NETEHVLVN 88

  Fly   125 QKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQ 189
            .|.:.:::|||.::|||.|.:........:....:||:|.:...||:..:|.|.::.:.:|.|.|
Worm    89 DKDILDKIWLPDLYFANARTAYFHKVTVHNFNMFISPQGTISYGTRVTLNLACNLDLKDYPLDYQ 153

  Fly   190 FCSTVLESWMYNTSDLILEWEPHTPISFDPEMRLTEYN-------------MAQFWHNTTIVQSD 241
            .|...:.|:.:..:::.:.|.|:.||.|:||:.|.|::             :....||::.|
Worm   154 TCYIKVISYAHVKNEMNVSWFPNDPIRFNPEIDLPEFHIRALDKDYCNGVFLYTLTHNSSRV--- 215

  Fly   242 GDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTST 306
                      |.:|.|...:.|||.|||:|:..|:|:.:||||||||||:...|.|.|:.|..:|
Worm   216 ----------GEFSCLLGMLKLKRAIGFHLVQSYIPTGLIVAISWVSFWIDRRAVPARVSLSFTT 270

  Fly   307 MLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTIWRR--KENIELKKVNSK 369
            :|:..|..:.....||.|||.|..:.::..|..||||.|:|||.||:..||  |.|...:|:.|.
Worm   271 LLTLSTQGNGIRYALPAVSYAKAIDYFYGVCMLFIFGVLLEFAAVNSYMRRANKYNHMAEKIQSA 335

  Fly   370 YIIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPI 434
            |               ||.                                            ||
Worm   336 Y---------------GGK--------------------------------------------PI 341

  Fly   435 IR---TECAEADTVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFL 496
            |.   ::..|..|....:...|:.|::            :..:.....|:.||:.:||.||.:|.
Worm   342 IADYDSDYEEGPTKYYGNLNKNSAHLM------------YKALKFSRKALSIDKAARFAFPCVFA 394

  Fly   497 AFNALYWTF 505
            .||..||.:
Worm   395 IFNVFYWLY 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	120/462 (26%)
		Neur_chan_LBD	44..267	CDD:280998	52/219 (24%)
		Neur_chan_memb	275..503	CDD:280999	62/232 (27%)
lgc-42	NP_497489.3	Neur_chan_LBD	36..192	CDD:280998	42/159 (26%)
lgc-42	NP_497489.3	Neur_chan_memb	239..401	CDD:280999	62/232 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910