Protein Alignment SecCl and lgc-54

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_001343648.1
• Gene: lgc-54 / 188525
• WormBaseID: WBGene00020528
• Length: 493
• Species: Caenorhabditis elegans
• Alignment Length: 466
• Identity: 108/466 - (23%)
• Similarity: 203/466 - (43%)
• Gaps: 68/466 - (14%)

  Fly    60 LERPFEYDSDGKRLPI-----VVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAF-NR 118
            |.|.|:.:.:...:|:     ||.....:..:..::.....|.:..|....:.|.||.:... |.
 Worm    56 LRRLFDDNYNKNTVPLKTSATVVSVEFGIQNIAQVSEISASFTLDLLFSQIWHDPRLRFDHLTNC 120

  Fly   119 SDNILGQKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQK 183
            ..|:.....:.|:||.|::.|.|.:::.|..:...::...:.|.|.|.::.|:|....|.::...
 Worm   121 LQNLTLGYSMVEKLWTPNVCFVNSKKTEIHSSPTPNIFLMIYPNGTVWVNYRLQVQSPCMVDLVL 185

  Fly   184 FPFDQQFCSTVLESWMYNTSDLILEWEPHTPISFDPEMRLTEYNMAQF-WHNTTIVQSDGDNLRH 247
            ||.|...|..::||:.||.:.:.|.|....|:....:.:|:::.:... |...:...:
 Worm   186 FPMDIMNCELIIESYAYNAAKVKLNWREWQPVFSIAKSKLSDFTLYGLQWTKNSFEYA------- 243

  Fly   248 GAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFIT 312
               ||.:..|:.::...|..|||:|..|:|:...|.:|:||||:...|.|.||.||.|::::...
 Worm   244 ---AGQWDQLTVSLTFSRAYGFYILQMYIPTYSSVFLSFVSFWIDLKALPARITLGVSSLMALTF 305

  Fly   313 LSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFV------NTIWRRKENIELKKVNSKYI 371
            ...:.:||||:|.|:|..:|:.:..|.|||.:::|.|||      |.:.|::...|.||  .:..
 Worm   306 QYGNVAKNLPRVGYVKSIDVYMVLTTAFIFLTMIEVAFVCYLDSENNLRRKERQAEKKK--ERVA 368

  Fly   372 IKSTLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVN-------QGFNNYLTVH 429
            :......|........:::|.:.|.|     ::.|:.:...:.|||.:       |..|.:.::|
 Worm   369 VLQRKKDRKKNNYGATTVTNANAAES-----DLRSNYDEPFSQNGTTSHKISISRQANNMFESLH 428

  Fly   430 PNLPIIRTECAEADTVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAM 494
                          .::.....|::|     |::.|.|            |..:|:..|..||..
 Worm   429 --------------ALAQFGLLTDDD-----DENTKWT------------AQNVDKFCRKAFPLS 462

  Fly   495 FLAFNALYWTF 505
            |...|.:||.:
 Worm   463 FCFLNLIYWCY 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	108/464 (23%)
lgc-54	NP_001343648.1	LIC	55..474	CDD:455710	108/466 (23%)
		LGIC_ECD_GABAAR	76..258	CDD:349791	38/191 (20%)
		Cys-loop	179..193	CDD:349791	4/13 (31%)