Protein Alignment SecCl and acc-2

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_501567.1
• Gene: acc-2 / 183758
• WormBaseID: WBGene00008280
• Length: 445
• Species: Caenorhabditis elegans
• Alignment Length: 470
• Identity: 113/470 - (24%)
• Similarity: 204/470 - (43%)
• Gaps: 93/470 - (19%)

  Fly    43 QQTQLIQRLTHVCRYDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQ 107
            :.|.:|.||.:...|::...|.|     :.:.:||:  |::..:.:::.....|.|...:...:.
 Worm    49 RDTDIIDRLLNGTGYNKFRIPQE-----EGMTVVVE--IWIQAITSIDELTNDFDMDIYITETWL 106

  Fly   108 DKRLAYKAFNRSDNILGQKH-LSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRM 171
            |..|.::........|...| :.:|||.|:..|.|.:.:.|..:..:.|...|.|.|.|:::.|:
 Worm   107 DPALNFQTMTPCKGNLSLNHQVLDRLWTPNSCFINSKVAQIHNSPFRSVFLMLFPNGTVMVNYRV 171

  Fly   172 QASLYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEW-EPHTPISFDPEMRLTEYNMAQFWHNT 235
            :....|.::...||.|.|.||.:.||:.||..::.:.| :...|:....::.|.::::.:
 Worm   172 RVKGPCSLDLSNFPLDLQKCSLIYESFNYNRQEVEMRWSDAEHPVFNLSKIMLPDFDLFE----- 231

  Fly   236 TIVQSDGDNLRHGAF-AGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPR 299
              :|::   .|...: ||.:..|..|:..:|...:|.:..|||:.:.:.|||:||.|.:.|.|.|
 Worm   232 --IQTE---RRQEPYPAGMWDELHVTIIFERRFIWYFMQAYLPTYLTIFISWISFSLGSRAIPAR 291

  Fly   300 IMLGTSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTIWRRKENIELK 364
            .|||.:::|:.:....:..:|||:|||||..:||.|....|||.||:|.|.|..:.|
 Worm   292 TMLGVNSLLAIVFSFGNIMRNLPRVSYIKGIDVWMLVSMTFIFCSLLELAIVGFMVR-------- 348

  Fly   365 KVNSKYIIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVH 429
                    ..|:..:..:::|.|::|.|      .|...|:|....
 Worm   349 --------DETVAKKKQQKKISGNISRE------ESPHGIISERRF------------------- 380

  Fly   430 PNLPIIRTECAEAD-TVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPA 493
                :....|:|:. ::|.|:                      :..||:.    ||..|..:||.
 Worm   381 ----MFPPGCSESSKSLSSCT----------------------SGWTPER----IDSISSVMFPF 415

  Fly   494 MFLAFNALYWTFVYV 508
            .|..||.:|| |.|:
 Worm   416 SFFVFNIIYW-FYYI 429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	111/465 (24%)
acc-2	NP_501567.1	LIC	52..428	CDD:455710	111/464 (24%)
		LGIC_ECD_GABAAR	76..258	CDD:349791	42/193 (22%)
		Cys-loop	177..191	CDD:349791	5/13 (38%)