Protein Alignment SecCl and lgc-41

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_001360683.1
• Gene: lgc-41 / 183331
• WormBaseID: WBGene00008022
• Length: 567
• Species: Caenorhabditis elegans
• Alignment Length: 593
• Identity: 148/593 - (24%)
• Similarity: 255/593 - (43%)
• Gaps: 131/593 - (22%)

  Fly    10 FWITLIL--VLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSDGKR 72
            :|.||.|  ||.|:..:...:...: |::.:.  |||:.              .||   .:....
 Worm     4 YWSTLHLFQVLCIFIFIRTSSPLTQ-PNIYNL--LQQSN--------------TRP---PTANAS 48

  Fly    73 LPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNIL-GQKHLSERLWLPH 136
            :|:.||..:|:..|.|..|..:.|.:...:.:.:||.|||:   |.||.:| ....:.:::|||.
 Worm    49 VPLGVKLGMYLESLGNFRSSEMSFDVDLYVYMSWQDPRLAH---NFSDYVLINNDEIRKQIWLPD 110

  Fly   137 IFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYN 201
            ::|||.|::|.......:....::|:|.|..|.|...::.|.:|.:.:|.|||.||..:.|:.|.
 Worm   111 LYFANARQASFQEVTVPNFNLFVAPDGTVAYSCRCTLTVACSLNLRYYPMDQQLCSIRVLSYAYI 175

  Fly   202 TSDLILEWEPHTPISFDPEMRLTEYNMA-----------QFWHNTTIVQSDGDNLRHGAFAGNYS 255
            ...:.:.|....|:.|:.|:.|.|:.:.           |:.......:||           ::|
 Worm   176 AKQVNVTWFDKNPVRFNEEIGLPEFQIEHVSNAYCNGSYQYALTENSYKSD-----------DFS 229

  Fly   256 SLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKN 320
            .||..:.|.|.||:.|:..|:|:.:||.|||||||:...|.|.|:.|..:|::|..||.:.....
 Worm   230 CLSGNLFLSRSIGYNLVQSYIPTGLIVMISWVSFWIDRRAVPARVTLSFTTLVSLTTLGNGLRFG 294

  Fly   321 LPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTIWRRKENIE--LKKVNS--------KYIIKST 375
            ||:|||.|..::|:..|.||:|.:|:|||.:|:..|:.|..:  .||:.|        .|:::..
 Worm   295 LPQVSYAKAIDLWYGACMFFVFCALLEFATINSYMRKSEKFDSMAKKMQSVVLTGRTRDYLVRGI 359

  Fly   376 LTPRPARRQIGGSLSN--------------ESRARSCSSL--------DNIVS---------STE 409
               :.:.|..||:..|              |:..:|.|::        .|.:|         .||
 Worm   360 ---KESMRIAGGAAGNVVDALNDDWCTYSTENGRKSFSAMVGDIFERAGNAISPRRNRYRGLKTE 421

  Fly   410 SVRNGNGT--------------VNQGF------------NNYLTVHPNLPIIRTECAEADTVSIC 448
            ....|.|.              ::..|            |..::::.|:...:.|...:...:..
 Worm   422 KSPRGYGKPDTVQDILSERIKFIDNEFDFDTKEDDEIPGNMAMSIYDNVSCRKDEADSSSEETKF 486

  Fly   449 SAR-----TNNDH-IVDVDKDKKDTPPTFTTMTPQEI-------AMWIDRRSRFLFPAMFLAFNA 500
            |.:     ||... .:|...::.....:....|..:|       |:.||:..|:||||.||.:|.
 Worm   487 STKPKRNGTNGTRKYIDKSLNQSGQNDSLIVATYFQISANHSRHALKIDKSCRYLFPAAFLLWNV 551

  Fly   501 LYWTFVYV 508
            .||.:..|
 Worm   552 FYWWYYLV 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	138/553 (25%)
lgc-41	NP_001360683.1	LIC	41..>332	CDD:455710	95/307 (31%)
		LGIC_TM	<527..557	CDD:476813	13/29 (45%)
		TM4 helix	533..554	CDD:349850	10/20 (50%)