Protein Alignment SecCl and lgc-49

DIOPT Version :9

• Sequence 1: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_505841.2
• Gene: lgc-49 / 179547
• WormBaseID: WBGene00010741
• Length: 457
• Species: Caenorhabditis elegans
• Alignment Length: 520
• Identity: 124/520 - (23%)
• Similarity: 213/520 - (40%)
• Gaps: 93/520 - (17%)

  Fly     1 MMNLHLSEIFWITLILV---------LSIWTSVGVKAEEE-ECPSMADAGSLQQTQLIQRLTHVC 55
            |.|......|:|.|||:         :.|.:...|.:::: ...:.......:|..:|.:|.:..
 Worm     1 MHNRKTPNSFFIFLILLSILQINICEIIIDSDYNVSSDDDPTTTTQKPRNCTRQPAIIDKLLNGT 65

  Fly    56 RYDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSD 120
            .|::...|.|   :|    :.|:...:|..:.::|.....|:|...:...:.|..|.:...|...
 Worm    66 GYNKFRIPNE---NG----VPVQVEFWVQAITSINEITNDFEMDIYINEMWLDPALKFDHLNPCK 123

  Fly   121 NILGQKH-LSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKF 184
            ..|...| :.|:||.|:..|.|.:.:.|..:..|:|...:.|.|.|.::.|:.....|.::.:.|
 Worm   124 QNLSVSHQVLEQLWTPNSCFVNSKFAEIHDSPFKNVFLMIYPNGTVWVNYRVNVKGPCDLSLELF 188

  Fly   185 PFDQQFCSTVLESWMYNTSDLILEWEPHT--PISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRH 247
            |.|.|.|..:.||:.||..::.:.|...:  |:|...::||.::.         :::.:...:..
 Worm   189 PLDIQECHLIYESFNYNNQEVRMRWNEKSAEPVSVTNKIRLPDFE---------LIKIESTRISA 244

  Fly   248 GAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFIT 312
            ...||.:..|...:..:|...:|.:..|||:.:.:.|||:||.|...|.|.|.|||.:.:|:.|.
 Worm   245 PYPAGMWDELHVKLVFERRYIWYFMQAYLPTYLTIFISWISFSLGTKAMPARTMLGVNALLAMIF 309

  Fly   313 LSSSQSKNLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTIWRRKENIELKKVNSKYIIKSTLT 377
            ...:..:|||:|||:|..:||.|....|||.||:|.|.|....:.:|..:.|..:.|.:.....:
 Worm   310 QFGNIMRNLPRVSYVKAIDVWMLVSMTFIFLSLLELAIVGYKTKNEEGSKKKCPHKKLLDNFEAS 374

  Fly   378 PRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECAEA 442
            |       .|....|.|..                                   ||:.|.
 Worm   375 P-------AGLCRYEKRFM-----------------------------------LPVERR----- 392

  Fly   443 DTVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYWTFVY 507
                  |||........|.:|       |...:|::    |||.|..:|||.|..||.:||::.|
 Worm   393 ------SARWGGIIRFQVFQD-------FWNWSPEK----IDRVSAIMFPACFAIFNIVYWSYYY 440

  Fly   508  507
             Worm   441  440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	114/464 (25%)
		Neur_chan_LBD	44..267	CDD:280998	49/225 (22%)
		Neur_chan_memb	275..503	CDD:280999	62/227 (27%)
lgc-49	NP_505841.2	LIC	53..439	CDD:273305	114/465 (25%)
		Neur_chan_LBD	57..264	CDD:280998	48/222 (22%)
		Neur_chan_memb	272..436	CDD:280999	62/227 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810