Protein Alignment SecCl and acc-1

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_001293865.1
• Gene: acc-1 / 177799
• WormBaseID: WBGene00010275
• Length: 470
• Species: Caenorhabditis elegans
• Alignment Length: 521
• Identity: 119/521 - (22%)
• Similarity: 215/521 - (41%)
• Gaps: 86/521 - (16%)

  Fly     2 MNLHLSEIFWI--TLILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRLERPF 64
            |...:|...||  :.:..|...:|.|:....:.|.:        .|::|..|..
 Worm     1 MTRWMSHPGWIMVSFLTELLSQSSKGIAQSLDNCAN--------DTEIINALLK----------- 46

  Fly    65 EYDSDGKRL----PIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNR-SDNILG 124
              ||..|..    |..|:..::|..:.:::.....|::...:...::|..|.|:..|. ..||..
 Worm    47 --DSYNKHYIPSHPTHVRVDMWVQEVTSVSELTQDFEIDLYINEFWEDPALVYEDMNPCKRNISF 109

  Fly   125 QKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQ 189
            ...:.:|||||:..|.|.:.::|..:..|:|...:...|.:..:.||:.:..|.|..::||||:|
 Worm   110 DDKVLQRLWLPNTCFINSKSAAIHESPFKNVFLMVFSNGTLWTNYRMKLTGPCDMKLKRFPFDKQ 174

  Fly   190 FCSTVLESWMYNTSDLILEWEPHTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNY 254
            .|....||:.|||.::.::|....|:.....:.|.::.:..|    :::.     :.....||.:
 Worm   175 KCYLTFESFNYNTGEVRMQWNQPYPVILLKRIELPDFKLVNF----SVIA-----VEQMYPAGWW 230

  Fly   255 SSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSK 319
            ..|:.....:|..|:|:|..|:|:|:.:.|||:||:|...|.|.|.|||.:::|:......:..:
 Worm   231 DELTVAFVFERRYGWYVLQGYIPTMVTIVISWISFYLGPRAIPARTMLGVNSLLAMTFQFGNIIR 295

  Fly   320 NLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVNTIWRRKENIELKKVNSKYIIKSTLTPRPARRQ 384
            |||:|||:|..:||.|....|||.||:|.|.|..:.|.:                .|.|:..:|:
 Worm   296 NLPRVSYVKAIDVWMLSGMLFIFLSLLELAVVGFMSRNE----------------GLPPKVKKRK 344

  Fly   385 IGGSLSNESRARSCSSLDN----------IVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTEC 439
               ...::....|..|:..          :.....|:||.:..  ....:|..:....|.
 Worm   345 ---RQEDDDEGFSWKSMQTSPHLELRQFWVDKRVNSLRNDSAV--PPVEDYAPMELEQPY----- 399

  Fly   440 AEADTVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYWT 504
                 .:|...|.....:..:.|..:    ....:.|:.    :|..|...||..::.||..||:
 Worm   400 -----QNITKRREKRKWMSGLRKKWR----AMRELRPET----VDFYSAIFFPTAYMLFNISYWS 451

  Fly   505 F 505
            |
 Worm   452 F 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	110/476 (23%)
acc-1	NP_001293865.1	LIC	39..453	CDD:455710	110/475 (23%)
		LGIC_ECD_GABAAR	59..242	CDD:349791	42/191 (22%)
		Cys-loop	162..176	CDD:349791	7/13 (54%)