Protein Alignment SecCl and Gabrg2

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_032099.1
• Gene: Gabrg2 / 14406
• MGIID: 95623
• Length: 474
• Species: Mus musculus
• Alignment Length: 542
• Identity: 116/542 - (21%)
• Similarity: 215/542 - (39%)
• Gaps: 136/542 - (25%)

  Fly    11 WITLILVLSIWTSVGVKAEEEECPSMAD-----------AGSLQQTQLIQRLTHVCRYDRLERPF 64
            ||  :|:||::.....:..:::....|.           .|.:  |.::..|..  .||...||
Mouse    25 WI--LLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDV--TVILNNLLE--GYDNKLRP- 82

  Fly    65 EYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAY----KAFNRSDNILGQ 125
              |...|  |.::.|.:||..:..:|:..:::.:.......:.|:||.:    |....:.|::|
Mouse    83 --DIGVK--PTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVG- 142

  Fly   126 KHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQF 190
                 ::|:|..||.|.:::........:.:..:..:|.|:.:.|:.....|.:....||.|:..
Mouse   143 -----KIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHS 202

  Fly   191 CSTVLESWMYNTSDLILEWE-PHTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNY 254
            |.....|:.|...:::.:|: ....:......||.:::.....:.|.:|::.         :|:|
Mouse   203 CPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTT---------SGDY 258

  Fly   255 SSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSK 319
            ..:|...:|.|.:|::.:..|:|..:||.:||||||:..||.|.|..||.:|:|:..|||:...|
Mouse   259 VVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARK 323

  Fly   320 NLPKVSYIKVSEVWFLGCTFFIFGSLVEFA----FVNTIWRRKENIELKKVNSKYIIKSTLTPRP 380
            :||||||:...:::...|..|:|.:|||:.    ||:.....|:. :.||.|
Mouse   324 SLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDK-DKKKKN------------- 374

  Fly   381 ARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECAEADTV 445
                                                                |::|....:|.|:
Mouse   375 ----------------------------------------------------PLLRMFSFKAPTI 387

  Fly   446 SI----CSARTNN-DHIVDVDK-------DKKDTPPTFTTMTPQEIAMW-----------IDRRS 487
            .|    .:.:.|| .|:.:.|:       |.||....|..........|           :|..:
Mouse   388 DIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYA 452

  Fly   488 RFLFPAMFLAFNALYW-TFVYV 508
            |..||..|..||.:|| :::|:
Mouse   453 RIFFPTAFCLFNLVYWVSYLYL 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	108/494 (22%)
Gabrg2	NP_032099.1	LIC	68..471	CDD:455710	107/490 (22%)
		LGIC_ECD_GABAAR_G	89..270	CDD:349801	34/195 (17%)
		Cys-loop	189..203	CDD:349801	4/13 (31%)