Protein Alignment SecCl and Gabra4

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_001345970.1
• Gene: Gabra4 / 14397
• MGIID: 95616
• Length: 578
• Species: Mus musculus
• Alignment Length: 572
• Identity: 144/572 - (25%)
• Similarity: 242/572 - (42%)
• Gaps: 106/572 - (18%)

  Fly    14 LILVLSIWTSVGVKAEEEE-CPSMADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSD-------- 69
            |.|...:..|.|..:::|: ||.       ..|:::..|  :..||...||....:|
Mouse    24 LCLAACLNESPGQNSKDEKLCPE-------NFTRILDSL--LDGYDNRLRPGFGGTDCFKTCKCA 79

  Fly    70 -GKRL-----------PIV-VKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKA---FNR 118
             ..||           |:. |||.|||.....::...:::.|....:..:.||||.|..   ..|
Mouse    80 LSVRLWSACLFVEILGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILR 144

  Fly   119 SDNILGQKHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQK 183
            .:|::..|     :|.|..||.|.::|........:.|..:...|.::.:.|:..|..|.|....
Mouse   145 LNNMMVTK-----VWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVD 204

  Fly   184 FPFDQQFCSTVLESWMYNTSDLILEWE--PHTPISFDPE-MRLTEYNMAQFWHNTTIVQSDGDNL 245
            ||.|...|.....|:.|..|::|..|.  |...:....| ..|.:|::.....::..::|
Mouse   205 FPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKS----- 264

  Fly   246 RHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSF 310
                ..|.|..::...:|:|::|::::..|:|.:|.|.:|.||||:..::.|.|.:.|.:|:|:.
Mouse   265 ----ITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTM 325

  Fly   311 ITLSSSQSKNLPKVSYIKVSEVWFLG-CTFFIFGSLVEFAFVN-----TIWRRKENIE------- 362
            .|||.|...:||||||....: ||:. |..|:|.:|:|||.||     .:.:.|:.|.
Mouse   326 TTLSISARHSLPKVSYATAMD-WFIAVCFAFVFSALIEFAAVNYFTNIQMQKAKKKISKPPPEVP 389

  Fly   363 ----LKKVNSKYIIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFN 423
                ||:.:::..:::|......|::....:.:||..:|.:.:.|..|.|.:|:..:....:.
Mouse   390 AAPVLKEKHTETSLQNTHANLNMRKRTNALVHSESDVKSRTEVGNHSSKTSAVQESSEATPKA-- 452

  Fly   424 NYLTVHPNLPIIRTECAE---ADTVSICSARTNNDH--IVDVDKDKKDTPPTF--------TTM- 474
             :|...|| |..|...||   |....:.||.:.:.|  :.........|.|.|        ||:
Mouse   453 -HLASSPN-PFSRANAAETMSAAARGLSSAASPSPHGTLRPASLGSASTRPAFGSRLGRIKTTVN 515

  Fly   475 ----------TPQEIA--------MWIDRRSRFLFPAMFLAFNALYWTFVYV 508
                      ||...|        ..||:.:|.|||..|.|||.:||. ||:
Mouse   516 TTGAAGNVSATPPPPAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWV-VYL 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	135/537 (25%)
Gabra4	NP_001345970.1	LIC	13..565	CDD:455710	142/569 (25%)
		LGIC_ECD_GABAAR_A4	57..281	CDD:349838	52/237 (22%)
		Cys-loop	198..212	CDD:349838	5/13 (38%)