Protein Alignment SecCl and Gabra3

DIOPT Version :9

• Sequence 1: NP_001261986.1
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_001344745.1
• Gene: Gabra3 / 14396
• MGIID: 95615
• Length: 523
• Species: Mus musculus
• Alignment Length: 545
• Identity: 137/545 - (25%)
• Similarity: 228/545 - (41%)
• Gaps: 110/545 - (20%)

  Fly     1 MMNLHLSEIFWITLILVLSIWTSVGVKAEEEECPS---MADAGSLQQ-----------------T 45
            |.:.:::.:..:.||.:|...||.|....:|  |.   ..|.|.|..                 |
Mouse    37 MWHFYVTRVVLLLLISILPGTTSQGESRRQE--PGDFVKQDIGGLSPKHAPDIPDDSTDNITIFT 99

  Fly    46 QLIQRLTHVCRYDRLERPFEYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKR 110
            :::.||  :..||...||...|:..:     |||.|||.....::...:::.:....:..:.|:|
Mouse   100 RILDRL--LDGYDNRLRPGLGDAVTE-----VKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDER 157

  Fly   111 LAYKAFNRSDNILGQKH-LSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQAS 174
            |   .|:....||...: |:.::|.|..||.|.::|........:.|..|...|.::.:.|:...
Mouse   158 L---KFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIH 219

  Fly   175 LYCWMNFQKFPFDQQFCSTVLESWMYNTSDLILEW----EPHTPISFDPEMRLTEYNMAQFWHNT 235
            ..|.|:.:.||.|...|.....|:.|..:::|..|    .....::.|.. ||.:|::......|
Mouse   220 AECPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKNKSVEVAQDGS-RLNQYDLLGHVVGT 283

  Fly   236 TIVQSDGDNLRHGAFAGNYSSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRI 300
            .|::|.         .|.|..::...:|||:||::::..|||.:|.|.:|.|||||..::.|.|.
Mouse   284 EIIRSS---------TGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPART 339

  Fly   301 MLGTSTMLSFITLSSSQSKNLPKVSYIKVSEVWFLG-CTFFIFGSLVEFAFVNTIWRRKENIELK 364
            :.|.:|:|:..|||.|...:||||:|....: ||:. |..|:|.:|:|||.||...:|....|.|
Mouse   340 VFGVTTVLTMTTLSISARNSLPKVAYATAMD-WFIAVCYAFVFSALIEFATVNYFTKRSWAWEGK 403

  Fly   365 KVNSKYIIKSTLTPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVH 429
            ||.....:|......|.::               ::..|||.:|
Mouse   404 KVPEALEMKKKTPAAPTKK---------------NTTFNIVGTT--------------------- 432

  Fly   430 PNLPIIRTECAEADTVSICSARTNNDHIVDVDKDKKDTP-------PTFTTMTPQEIAMW----- 482
              .||...:..|..|:|..:|..:          ...||       .|:...:|.|...:
Mouse   433 --YPINLAKDTEFSTISKSAAAPS----------ASSTPTAIASPKATYVQDSPAETKTYNSVSK 485

  Fly   483 IDRRSRFLFPAMFLAFNALYW-TFV 506
            :|:.||.:||.:|..||.:|| |:|
Mouse   486 VDKISRIIFPVLFAIFNLVYWATYV 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	123/497 (25%)
		Neur_chan_LBD	44..267	CDD:280998	53/244 (22%)
		Neur_chan_memb	275..503	CDD:280999	66/240 (28%)
Gabra3	NP_001344745.1	Neur_chan_LBD	100..509	CDD:332142	122/477 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900