Protein Alignment SecCl and Gabra2

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_032092.1
• Gene: Gabra2 / 14395
• MGIID: 95614
• Length: 451
• Species: Mus musculus
• Alignment Length: 510
• Identity: 137/510 - (26%)
• Similarity: 225/510 - (44%)
• Gaps: 100/510 - (19%)

  Fly    11 WITLILVLSIWTSVGV---KAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSDGKR 72
            | :|:|||.:|..|.:   ..:|:|    |.......|:::.||  :..||...||...||..:
Mouse    11 W-SLLLVLLVWDPVRLVLANIQEDE----AKNNITIFTRILDRL--LDGYDNRLRPGLGDSITE- 67

  Fly    73 LPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHL-SERLWLPH 136
                |.|.|||.....::...:::.:....:.:::|:||.:|.   ..|||...:| :.::|.|.
Mouse    68 ----VFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKG---PMNILRLNNLMASKIWTPD 125

  Fly   137 IFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYN 201
            .||.|.::|........:.|..:..:|.::.:.|:.....|.|:.:.||.|...|.....|:.|.
Mouse   126 TFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYT 190

  Fly   202 TSDLILEW--EPHTPISFDPE-MRLTEYN-MAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVN 262
            ||::...|  .....:...|: .||.:|: :.|.....||..|.|:          |:.::...:
Mouse   191 TSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGE----------YTVMTAHFH 245

  Fly   263 LKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYI 327
            |||:||::::..|||.:|.|.:|.|||||..::.|.|.:.|.:|:|:..|||.|...:||||:|.
Mouse   246 LKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYA 310

  Fly   328 KVSEVWFLG-CTFFIFGSLVEFAFVNTIWRRKENIELKK-VNSKYIIKSTLTPRPARRQIGGSLS 390
            ...: ||:. |..|:|.:|:|||.||...:|....:.|. ||.|            :::.|
Mouse   311 TAMD-WFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDK------------KKEKG---- 358

  Fly   391 NESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNL---PIIRTECAEADTVSICSART 452
                               ||...|........||.   |||   |::.|....|.|
Mouse   359 -------------------SVMIQNNAYAVAVANYA---PNLSKDPVLSTISKSATT-------- 393

  Fly   453 NNDHIVDVDKDKKDTP----PTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYW 503
                 .:.:|..::.|    .||.:::.      |||.||.:||.:|..||.:||
Mouse   394 -----PEPNKKPENKPAEAKKTFNSVSK------IDRMSRIVFPVLFGTFNLVYW 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	127/475 (27%)
Gabra2	NP_032092.1	LIC	25..440	CDD:455710	130/495 (26%)
		LGIC_ECD_GABAAR_A2	47..249	CDD:349836	53/221 (24%)
		Cys-loop	166..180	CDD:349836	5/13 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..408		4/31 (13%)