Protein Alignment SecCl and Gabra1

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: XP_006532258.1
• Gene: Gabra1 / 14394
• MGIID: 95613
• Length: 553
• Species: Mus musculus
• Alignment Length: 516
• Identity: 137/516 - (26%)
• Similarity: 225/516 - (43%)
• Gaps: 102/516 - (19%)

  Fly     6 LSEIFWI-TLILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLTHVCRYDRLERPFEYDSD 69
            ||:..|. ||||......|.|..:::|    :.| .:...|:::.||  :..||...||    ..
Mouse   105 LSDYLWAWTLILSTLSGRSYGQPSQDE----LKD-NTTVFTRILDRL--LDGYDNRLRP----GL 158

  Fly    70 GKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYK---AFNRSDNILGQKHLSER 131
            |:|: ..|||.|:|.....::...:::.:....:..::|:||.:|   ...|.:|::..|
Mouse   159 GERV-TEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK----- 217

  Fly   132 LWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLE 196
            :|.|..||.|.::|........:.|..::.:|.::.:.|:.....|.|:.:.||.|...|.....
Mouse   218 IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHACPLKFG 282

  Fly   197 SWMYNTSDLILEW--EP-HTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNYSSLS 258
            |:.|..::::.||  || .:.:..:...||.:|::.....::.||||.         .|.|..::
Mouse   283 SYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSS---------TGEYVVMT 338

  Fly   259 FTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPK 323
            ...:|||:||::::..|||.:|.|.:|.|||||..::.|.|.:.|.:|:|:..|||.|...:|||
Mouse   339 THFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPK 403

  Fly   324 VSYIKVSEVWFLG-CTFFIFGSLVEFAFVNTI------WRRKENI--ELKKVNSKYIIKSTLTPR 379
            |:|....: ||:. |..|:|.:|:|||.||..      |..|..:  :.|||... :||...|..
Mouse   404 VAYATAMD-WFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP-LIKKNNTYA 466

  Fly   380 PARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECAEADT 444
            |.......:|     ||....|..|..|.                  |:.|.
Mouse   467 PTATSYTPNL-----ARGDPGLATIAKSA------------------TIEPK------------- 495

  Fly   445 VSICSARTNNDHIVDVDKDKKDTPP--TFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYW 503
                          :|..:.|...|  ||.:::.      |||.||..||.:|..||.:||
Mouse   496 --------------EVKPETKPPEPKKTFNSVSK------IDRLSRIAFPLLFGIFNLVYW 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	126/478 (26%)
Gabra1	XP_006532258.1	LIC	105..539	CDD:455710	137/516 (27%)
		LGIC_ECD_GABAAR_A1	153..346	CDD:349835	48/211 (23%)
		Cys-loop	263..277	CDD:349835	5/13 (38%)