DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment SecCl and Gabrg1

DIOPT Version :9

Sequence 1:NP_001261986.1 Gene:SecCl / 39949 FlyBaseID:FBgn0036727 Length:509 Species:Drosophila melanogaster
Sequence 2:NP_542153.1 Gene:Gabrg1 / 140674 RGDID:621732 Length:465 Species:Rattus norvegicus


Alignment Length:534 Identity:122/534 - (22%)
Similarity:221/534 - (41%) Gaps:129/534 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 ITLILVLSIWTSVGVKAEEEE------------CPSMADAGSLQQTQLIQRLTHVCRYDRLERPF 64
            |.|:|.|.:...:. ||::|:            .|.:.: |.:  ||::..|..  .||...|| 
  Rat    24 IFLLLTLHLGNCID-KADDEDDEDLTMNKTWVLAPKIHE-GDI--TQILNSLLQ--GYDNKLRP- 81

  Fly    65 EYDSDGKRLPIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAY----KAFNRSDNILGQ 125
               ..|.| |.|::|.:||..:..::...:::.:..:....:.|.||.:    |....:.|::| 
  Rat    82 ---DIGVR-PTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVG- 141

  Fly   126 KHLSERLWLPHIFFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQF 190
                 ::|:|..||.|.|:|........:.|..:..:|.|:.:.|:..:..|::....||.|:..
  Rat   142 -----KIWIPDTFFRNSRKSDAHWITTPNRLLRIWSDGRVLYTLRLTINAECYLQLHNFPMDEHS 201

  Fly   191 CSTVLESWMYNTSDLILEWEPHTPISFDPE-MRLTEYNMAQFWHNTTIVQSDGDNLRHGAFAGNY 254
            |.....|:.|..:::..:|:..:....||: .||.::......::|.|..:         .:|:|
  Rat   202 CPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEISHT---------ISGDY 257

  Fly   255 SSLSFTVNLKREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSK 319
            ..::...:|.|.:|::.:..|:|.::.|.:||||||:..||.|.|..||.:|:|:..|||:...|
  Rat   258 IIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARK 322

  Fly   320 NLPKVSYIKVSEVWFLGCTFFIFGSLVEFAFVN--TIWRRKENIELKKVNSKYIIK------STL 376
            :||||||:...:::...|..|:|.:|:|:..::  |...:.:....:|:.||..:.      |||
  Rat   323 SLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNNKGKTTRDRKLKSKTSVSPGLHAGSTL 387

  Fly   377 TPRPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECAE 441
            .|                      ::||            ::.||.::|          ..:|.|
  Rat   388 IP----------------------MNNI------------SMPQGEDDY----------GYQCLE 408

  Fly   442 ADTVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMW-----------IDRRSRFLFPAMF 495
            .                      ||....|..........|           ||..||..||..|
  Rat   409 G----------------------KDCATFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAF 451

  Fly   496 LAFNALYWT-FVYV 508
            ..||.:||. ::|:
  Rat   452 ALFNLVYWVGYLYL 465

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SecClNP_001261986.1 LIC 43..505 CDD:273305 112/486 (23%)
Neur_chan_LBD 44..267 CDD:280998 49/227 (22%)
Neur_chan_memb 275..503 CDD:280999 60/246 (24%)
Gabrg1NP_542153.1 Neur_chan_LBD 65..270 CDD:280998 49/226 (22%)
LIC 66..462 CDD:273305 111/483 (23%)
Neur_chan_memb 277..459 CDD:280999 60/247 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3644
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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