DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SecCl and Glra3

DIOPT Version :9

Sequence 1:	NP_001261986.1	Gene:	SecCl / 39949	FlyBaseID:	FBgn0036727	Length:	509	Species:	Drosophila melanogaster
Sequence 2:	NP_446176.3	Gene:	Glra3 / 114516	RGDID:	621229	Length:	480	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	139/515 - (26%)
Similarity:	233/515 - (45%)	Gaps:	91/515 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FWITLILVLSIWTSVGVKAEEEECPSMADAGSLQQTQLIQRLT-HVCRYDRLERPFEYDSDGKRL 73
            ||...:|:..:.|.....|.....|       :..:..:.:|. ....||...||     :.|..
  Rat    32 FWEAALLLSLVATKETNSARSRSAP-------MSPSDFLDKLMGRTSGYDARIRP-----NFKGP 84

  Fly    74 PIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHLSERLWLPHIF 138
            |:.|...|::....::....:.::::..|:.::.|.||||..: ..|::.....:.:.:|.|.:|
  Rat    85 PVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEY-PDDSLDLDPSMLDSIWKPDLF 148

  Fly   139 FANERESSI--LGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYN 201
            ||||:.::.  :.||.|  |..:...|||:.|.|:..:|.|.|:.:.||.|.|.|...|||:.|.
  Rat   149 FANEKGANFHEVTTDNK--LLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYT 211

  Fly   202 TSDLILEWEPHTPISFDPEMRLTEYNMAQFWHNTTIVQSDGDNLRHGA---FAGNYSSLSFTVNL 263
            .:|||.||:...|:.....:.|.::          :::.:.| ||:..   ..|.::.:....:|
  Rat   212 MNDLIFEWQDEAPVQVAEGLTLPQF----------LLKEEKD-LRYCTKHYNTGKFTCIEVRFHL 265

  Fly   264 KREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIK 328
            :|::|:||:..|:||::||.:||||||:..||:|.|:.||.:|:|:..|.||....:||||||:|
  Rat   266 ERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVK 330

  Fly   329 VSEVWFLGCTFFIFGSLVEFAFVNTIWRRKENIELKKVNSKYIIKSTLTPRPARRQIGGSLSNES 393
            ..::|...|..|:|.:|:|:|.||.:.|:.              |..|..|..|:....:.:.|.
  Rat   331 AIDIWMAVCLLFVFSALLEYAAVNFVSRQH--------------KELLRFRRKRKNKTEAFALEK 381

  Fly   394 RARSCSSLDNIVSSTES---------VRNGNGTVNQGFNNYLTVHPNLPIIRTECAEADTVSICS 449
            ..|...:.|.:..|..|         ::..:|.|.:|.|:.:.|.|.         .||.:
  Rat   382 FYRFSDTDDEVRESRFSFTAYGMGPCLQAKDGVVPKGPNHAVQVMPK---------SADEM---- 433

  Fly   450 ARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYWTFVYVL 509
                  ..|.:|:.||                 ||..||..||..||.||..||....:|
  Rat   434 ------RKVFIDRAKK-----------------IDTISRACFPLAFLIFNIFYWVIYKIL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_001261986.1	LIC	43..505	CDD:273305	132/476 (28%)
		Neur_chan_LBD	44..267	CDD:280998	57/228 (25%)
		Neur_chan_memb	275..503	CDD:280999	70/236 (30%)
Glra3	NP_446176.3	LIC	28..467	CDD:273305	138/510 (27%)
		Neur_chan_LBD	63..269	CDD:280998	57/224 (25%)
		Neur_chan_memb	276..464	CDD:280999	70/237 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910