Protein Alignment SecCl and CHRNB3

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: NP_000740.1
• Gene: CHRNB3 / 1142
• HGNCID: 1963
• Length: 458
• Species: Homo sapiens
• Alignment Length: 223
• Identity: 43/223 - (19%)
• Similarity: 65/223 - (29%)
• Gaps: 75/223 - (33%)

  Fly    81 VLNKPPKLPVKGNVP---IHNSMD------------ALAAAALSFGNDEGP--------RLVHRL 122
            |::.|.:|..|.:.|   ..:|::            .|....|:.|.:.||        .|..||
Human   384 VMSTPSELSCKESSPSWSTDSSLEPVLPGSPTPSRVRLPCQTLAPGPELGPSTAELKLEALTQRL 448

  Fly   123 DRETSG----------------LLVMGRTKESIDYLHSVFSDYKGRNSSC--KAWNKACEAMYQQ 169
            :||...                ..|.|:.....|:|:|.|.....|...|  ...:...:|:.:.
Human   449 EREMDAHPKADYFGRKLRGKAFYFVNGKVFCEEDFLYSGFQQSADRCFLCGHLIMDMILQALGKS 513

  Fly   170 YWALVIGSPKEKEGLISAPLSKVLLDDGKTDRVVLAQGSGFEASQD----AITEY-KVLGPKING 229
            |          ..|.....:....||           |..|....:    .:.:| |||.||...
Human   514 Y----------HPGCFRCVICNECLD-----------GVPFTVDSENKIYCVRDYHKVLAPKCAA 557

  Fly   230 CSWVELRP--------ITSRKHQLRVHC 249
            |....|.|        :.|......|.|
Human   558 CGLPILPPEGSDETIRVVSMDRDYHVEC 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	43/223 (19%)
CHRNB3	NP_000740.1	LIC	23..449	CDD:455710	13/64 (20%)