Protein Alignment SecCl and gabra2a

DIOPT Version :10

• Sequence 1: NP_648984.2
• Gene: SecCl / 39949
• FlyBaseID: FBgn0036727
• Length: 509
• Species: Drosophila melanogaster
• Sequence 2: XP_009305482.1
• Gene: gabra2a / 100150704
• ZFINID: ZDB-GENE-141216-16
• Length: 451
• Species: Danio rerio
• Alignment Length: 515
• Identity: 136/515 - (26%)
• Similarity: 225/515 - (43%)
• Gaps: 112/515 - (21%)

  Fly    10 FWITLILVLSIWTSVGVKAEEEECPSMADAGSLQQ-TQLIQRLTHVCRYDRLERPFEYDSDGKRL 73
            |.|.|.| |.:|.:.   :|.|...|.|...::.. |:::.||  :..||...||    ..|.|:
Zfish    11 FLIHLFL-LVLWRAC---SEAEVSGSDAFKNNITLFTRILDRL--LDGYDNRLRP----GLGDRV 65

  Fly    74 PIVVKTRIYVYFLQNLNSDLLQFKMHALLQLRFQDKRLAYKAFNRSDNILGQKHL-SERLWLPHI 137
             ..|||.|||.....::...:::.:....:.|:.|:||   .|:...|||...:| :.::|.|..
Zfish    66 -TEVKTDIYVTSFGPVSDTDMEYTVDVFFRQRWTDERL---KFHGPMNILRLNNLMASKIWTPDT 126

  Fly   138 FFANERESSILGTDEKDVLTSLSPEGNVIISTRMQASLYCWMNFQKFPFDQQFCSTVLESWMYNT 202
            ||.|.::|........:.|..:...|.::.:.|:.....|.|:.:.||.|...|.....|:.|..
Zfish   127 FFHNGKKSVAHNMTMPNKLLRIMENGTLLYTMRLTVQAECPMHLEDFPMDFHSCPLKFGSYAYTL 191

  Fly   203 SDLILEWEPHTPISFD--PE-MRLTEYN-MAQFWHNTTIVQSDGDNLRHGAFAGNYSSLSFTVNL 263
            :::...|..:..:|.:  |: .||.:|: |.|.....||..|.|:          |:.::...:|
Zfish   192 TEVTYVWTRNATLSVEVAPDGSRLNQYDLMGQTVGKETIKSSTGE----------YTVMTAHFHL 246

  Fly   264 KREIGFYLLDYYLPSMMIVAISWVSFWLQADASPPRIMLGTSTMLSFITLSSSQSKNLPKVSYIK 328
            ||:||::::..|||.:|.|.:|.|||||..::.|.|.:.|.:|:|:..|||.|...:||||:|..
Zfish   247 KRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYAT 311

  Fly   329 VSEVWFLG-CTFFIFGSLVEFAFVNTI------W--------RRKENIELKKVNSKYIIKSTLTP 378
            ..: ||:. |..|:|.:|:|||.||..      |        ::||...:||.|:..:..:...|
Zfish   312 AMD-WFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSIVNDKKKETSVMKKNNAYAVAVANYAP 375

  Fly   379 RPARRQIGGSLSNESRARSCSSLDNIVSSTESVRNGNGTVNQGFNNYLTVHPNLPIIRTECAEAD 443
            ..|:.               |:|..:..|.                  |..|         ::|.
Zfish   376 HIAKD---------------SALPTVSKSA------------------TPEP---------SKAQ 398

  Fly   444 TVSICSARTNNDHIVDVDKDKKDTPPTFTTMTPQEIAMWIDRRSRFLFPAMFLAFNALYW 503
            .|:                  |:|..||.:::.      |||.||.:||.:|.:||.:||
Zfish   399 PVA------------------KETKKTFNSVSK------IDRMSRIIFPVLFGSFNLVYW 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SecCl	NP_648984.2	LIC	43..505	CDD:455710	126/482 (26%)
gabra2a	XP_009305482.1	LIC	17..437	CDD:455710	133/509 (26%)
		LGIC_ECD_GABAAR_A2	47..249	CDD:349836	55/221 (25%)
		Cys-loop	166..180	CDD:349836	5/13 (38%)