Protein Alignment CG12229 and pykA

DIOPT Version :10

• Sequence 1: NP_648980.1
• Gene: CG12229 / 39945
• FlyBaseID: FBgn0036723
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_416368.1
• Gene: pykA / 946527
• ECOCYCID: EG10803
• Length: 480
• Species: Escherichia coli
• Alignment Length: 522
• Identity: 107/522 - (20%)
• Similarity: 197/522 - (37%)
• Gaps: 114/522 - (21%)

  Fly    64 ARRRKRKRYYHLGLVAKLVTETTHD-ELRRMLENGTYTFHVDTVGNKPDELKAILDTMNIAISAH 127
            :||.:|.:     :|..|...|..| .|.:::..|.....::.....|::.|...|.:
E. coli     2 SRRLRRTK-----IVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKV------- 54

  Fly   128 SAERELRLTTGLALEINGECCRVGRLRNNCTVMLARGGVVTLTTDESY-------RYKGFKEIVY 185
               ||:....|..:.|.|: .:..::|    |...:.|.|.|...:.:       :.:|.||.|
E. coli    55 ---REIAAKLGRHVAILGD-LQGPKIR----VSTFKEGKVFLNIGDKFLLDANLGKGEGDKEKV- 110

  Fly   186 VINLRCYLASVQLGDIVMI--GR------EVRGKVVKTLREALTVMIIDAGLVASYDFIELPRQC 242
            .|:.:...|.|..|||:::  ||      ||:|..|.|   .:||    .|.:::...|.  :..
E. coli   111 GIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFT---EVTV----GGPLSNNKGIN--KLG 166

  Fly   243 HALDPDLYPDLYMKDLEMAASLNANYVVLPKIRCKSFLR-AVRQTLNSDFNLKLIGMID-FEYVR 305
            ..|..:...:....|::.||.:..:|:.:...||...|. |.|...::..:.|::..:: .|.|.
E. coli   167 GGLSAEALTEKDKADIKTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVC 231

  Fly   306 S-NMLDLLGIIKLVDYIWI-----------PDMFNVNCCVY---NYIMEDVLPISQCQKKPVIGT 355
            | :.:|  .||...|.:.:           |::..:...:.   ..:...|:..:|..:..:...
E. coli   232 SQDAMD--DIILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNP 294

  Fly   356 VPLERCSDFKRFELHD----FLWKVDAIHIQKSPWCNKYP-----------LIVKKL--MPIKDY 403
            :|       .|.|:.|    .|...||:.:.......:||           |..:|:  :.:..:
E. coli   295 MP-------TRAEVMDVANAVLDGTDAVMLSAETAAGQYPSETVAAMARVCLGAEKIPSINVSKH 352

  Fly   404 RVGAVQNKMVLKSILTSYQTIVNFIIRTISSIECQAIFLFTTCETASVAL--SRIEIYCPVYVMV 466
            |:. ||...|.::|..|.....|. ::.:::|       .|..|:...||  |||....|::.|.
E. coli   353 RLD-VQFDNVEEAIAMSAMYAANH-LKGVTAI-------ITMTESGRTALMTSRISSGLPIFAMS 408

  Fly   467 PLEETDDAETITCKVELARALHLRRNMHPVLYTKDLNECSYSPIEFGVDFMRKKGCLEVGDFVVT 531
            ..|.|            .....|.|.:.||.:  |......:.....|:.:|.||.|..||.|:.
E. coli   409 RHERT------------LNLTALYRGVTPVHF--DSANDGVAAASEAVNLLRDKGYLMSGDLVIV 459

  Fly   532 LE 533
            .:
E. coli   460 TQ 461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12229	NP_648980.1	Pyruvate_Kinase	126..530	CDD:453956	94/454 (21%)
pykA	NP_416368.1	PRK05826	3..469	CDD:235619	107/521 (21%)