Protein Alignment CG12229 and PYK2

DIOPT Version :10

• Sequence 1: NP_648980.1
• Gene: CG12229 / 39945
• FlyBaseID: FBgn0036723
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_014992.3
• Gene: PYK2 / 854529
• SGDID: S000005874
• Length: 506
• Species: Saccharomyces cerevisiae
• Alignment Length: 506
• Identity: 109/506 - (21%)
• Similarity: 192/506 - (37%)
• Gaps: 132/506 - (26%)

  Fly    90 LRRMLENGTYTFHVDTVGNKPDELKAILDTMNIAISAHSAERELRLTTGLALEINGECCRVGRLR 154
            :|....:|:|.||...:.|                :..|.::.......:||:..|...|.||..
Yeast    50 IRLNFSHGSYEFHQSVIEN----------------AVKSEQQFPGRPLAIALDTKGPEIRTGRTL 98

  Fly   155 NNCTVMLARGGVVTLTTDESYRYKGFKEIVYVINLRCYLASVQLGDIVMIGREV-------RGKV 212
            |:..:.:.....:..|||.|:......:|:|:       ....|..:::.||.:       ..||
Yeast    99 NDQDLYIPVDHQMIFTTDASFANTSNDKIMYI-------DYANLTKVIVPGRFIYVDDGILSFKV 156

  Fly   213 VKTLREA-LTVMIIDAGLVASYDFIELPRQCHALDPDLYP----DLYMKDLEMAASLNANYVVLP 272
            ::.:.|: |.|..:::|.:||:..:.||.    .|.||.|    |  ||||:.......:.|...
Yeast   157 LQIIDESNLRVQAVNSGYIASHKGVNLPN----TDVDLPPLSAKD--MKDLQFGVRNGIHIVFAS 215

  Fly   273 KIRCKSFLRAVRQTLNSD-FNLKLIGMIDFEYVRSNMLDLLGIIKLVDYIWI-----------PD 325
            .||....:.::|:.|.|: .::|:|..|:.:....|..:   |:::.|.:.|           |:
Yeast   216 FIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDE---ILEVTDGVMIARGDLGIEILAPE 277

  Fly   326 MFNVNCCVYNYIMEDVLPISQCQ--KKPVI-GTVPLERCSDF---KRFELHD----FLWKVDAIH 380
            :..:...:          |::|.  .|||| .|..|:..:..   .|.|:.|    .|...|.:.
Yeast   278 VLAIQKKL----------IAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVM 332

  Fly   381 IQKSPWCNKYPLIVKKLMPIKDYRVGAVQNKMVLKSILTSYQTIVNFII---------------R 430
            :........||             |.||  .::..:.|.:..||.:..:               .
Yeast   333 LSGETAKGDYP-------------VNAV--NIMAATALIAESTIAHLALYDDLRDATPKPTSTTE 382

  Fly   431 TISSIECQAIF---------LFTTCETASVALSRIEIYCPVYVMVPLEETDDAETITCKVELARA 486
            |:::....||.         |.||..||.: ||:....||:.:            :|.....||.
Yeast   383 TVAAAATAAILEQDGKAIVVLSTTGNTARL-LSKYRPSCPIIL------------VTRHARTARI 434

  Fly   487 LHLRRNMHPVLY----TKDLNECSYSPIEFGVDFMRKKGCLEVGDFVVTLE 533
            .||.|.:.|.||    ..|..|..:..::|||:..|..|.::.||.||:::
Yeast   435 AHLYRGVFPFLYEPKRLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQ 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12229	NP_648980.1	Pyruvate_Kinase	126..530	CDD:453956	101/465 (22%)
PYK2	NP_014992.3	Pyruvate_Kinase	20..502	CDD:238178	109/506 (22%)