DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12229 and PYK2

DIOPT Version :9

Sequence 1:	NP_648980.1	Gene:	CG12229 / 39945	FlyBaseID:	FBgn0036723	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_014992.3	Gene:	PYK2 / 854529	SGDID:	S000005874	Length:	506	Species:	Saccharomyces cerevisiae

Alignment Length:	506	Identity:	109/506 - (21%)
Similarity:	192/506 - (37%)	Gaps:	132/506 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 LRRMLENGTYTFHVDTVGNKPDELKAILDTMNIAISAHSAERELRLTTGLALEINGECCRVGRLR 154
            :|....:|:|.||...:.|                :..|.::.......:||:..|...|.||..
Yeast    50 IRLNFSHGSYEFHQSVIEN----------------AVKSEQQFPGRPLAIALDTKGPEIRTGRTL 98

  Fly   155 NNCTVMLARGGVVTLTTDESYRYKGFKEIVYVINLRCYLASVQLGDIVMIGREV-------RGKV 212
            |:..:.:.....:..|||.|:......:|:|:       ....|..:::.||.:       ..||
Yeast    99 NDQDLYIPVDHQMIFTTDASFANTSNDKIMYI-------DYANLTKVIVPGRFIYVDDGILSFKV 156

  Fly   213 VKTLREA-LTVMIIDAGLVASYDFIELPRQCHALDPDLYP----DLYMKDLEMAASLNANYVVLP 272
            ::.:.|: |.|..:::|.:||:..:.||.    .|.||.|    |  ||||:.......:.|...
Yeast   157 LQIIDESNLRVQAVNSGYIASHKGVNLPN----TDVDLPPLSAKD--MKDLQFGVRNGIHIVFAS 215

  Fly   273 KIRCKSFLRAVRQTLNSD-FNLKLIGMIDFEYVRSNMLDLLGIIKLVDYIWI-----------PD 325
            .||....:.::|:.|.|: .::|:|..|:.:....|..:   |:::.|.:.|           |:
Yeast   216 FIRTSEDVLSIRKALGSEGQDIKIISKIENQQGLDNFDE---ILEVTDGVMIARGDLGIEILAPE 277

  Fly   326 MFNVNCCVYNYIMEDVLPISQCQ--KKPVI-GTVPLERCSDF---KRFELHD----FLWKVDAIH 380
            :..:...:          |::|.  .|||| .|..|:..:..   .|.|:.|    .|...|.:.
Yeast   278 VLAIQKKL----------IAKCNLAGKPVICATQMLDSMTHNPRPTRAEVSDVGNAVLDGADCVM 332

  Fly   381 IQKSPWCNKYPLIVKKLMPIKDYRVGAVQNKMVLKSILTSYQTIVNFII---------------R 430
            :........||             |.||  .::..:.|.:..||.:..:               .
Yeast   333 LSGETAKGDYP-------------VNAV--NIMAATALIAESTIAHLALYDDLRDATPKPTSTTE 382

  Fly   431 TISSIECQAIF---------LFTTCETASVALSRIEIYCPVYVMVPLEETDDAETITCKVELARA 486
            |:::....||.         |.||..||.: ||:....||:.:            :|.....||.
Yeast   383 TVAAAATAAILEQDGKAIVVLSTTGNTARL-LSKYRPSCPIIL------------VTRHARTARI 434

  Fly   487 LHLRRNMHPVLY----TKDLNECSYSPIEFGVDFMRKKGCLEVGDFVVTLE 533
            .||.|.:.|.||    ..|..|..:..::|||:..|..|.::.||.||:::
Yeast   435 AHLYRGVFPFLYEPKRLDDWGEDVHRRLKFGVEMARSFGMVDNGDTVVSIQ 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12229	NP_648980.1	pyruv_kin	103..530	CDD:273424	102/488 (21%)
CG12229	NP_648980.1	Pyruvate_Kinase	126..530	CDD:304951	101/465 (22%)
PYK2	NP_014992.3	Pyruvate_Kinase	20..502	CDD:238178	109/506 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870