DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12229 and PKp3

DIOPT Version :9

Sequence 1:	NP_648980.1	Gene:	CG12229 / 39945	FlyBaseID:	FBgn0036723	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_564402.1	Gene:	PKp3 / 840138	AraportID:	AT1G32440	Length:	571	Species:	Arabidopsis thaliana

Alignment Length:	553	Identity:	115/553 - (20%)
Similarity:	191/553 - (34%)	Gaps:	174/553 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 EDENRLEKFTVRLNGQHDL------EQRLKDFKAACEAHEKHARRRKRKRYYHLG-------LVA 79
            ||..:.:.:..  ||..|:      ..||.|.:.:     .:..|||.|....:|       ::.
plant    61 EDSRKPKAYAE--NGAFDVGVLDSSSYRLADSRTS-----SNDSRRKTKIVCTIGPSSSSREMIW 118

  Fly    80 KLVTETTHDELRRMLENGTYTFHVDTVGNKPDELKAILDTMNIAISAHSAERELR---LTTGLAL 141
            || .|...:..|..:.:|.:..|..|: :...|..::.....|||...:...|:|   :...:.|
plant   119 KL-AEAGMNVARLNMSHGDHASHQITI-DLVKEYNSLFVDKAIAIMLDTKGPEVRSGDVPQPIFL 181

  Fly   142 EINGECCRVGRLRNNCTVMLARGGVVTLTTDESYRYKGFKEIVYVINLRCYLASVQLGDIVMIGR 206
            |...|.        |.|:  .||  |:|....|..|..|      :|      .|::|||:::..
plant   182 EEGQEF--------NFTI--KRG--VSLKDTVSVNYDDF------VN------DVEVGDILLVDG 222

  Fly   207 EVRGKVVKT-LREALTVMIIDAGLVASYDFIELPRQCHALDPDLYPDLYMKDLEMAASLNANYVV 270
            .:....||: ..:.:..::||.|        ||..:.|                  .::......
plant   223 GMMSLAVKSKTSDLVKCVVIDGG--------ELQSRRH------------------LNVRGKSAT 261

  Fly   271 LPKIRCKSFLRAVRQTLNSDFNLKLIGMIDF----------------EYVRSNMLDLLGIIKL-- 317
            ||.|..|.:         .|....:...:||                .|:::...|:..|:|:
plant   262 LPSITDKDW---------EDIKFGVDNQVDFYAVSFVKDAKVVHELKNYLKTCSADISVIVKIES 317

  Fly   318 VDYIW-IPDMFNVNCC----VYNYIMEDVLPISQ-----------CQK--KPVI-GTVPLERCSD 363
            .|.|. :|.:  ::.|    |....:...|||.:           |:.  |||| .|..||...:
plant   318 ADSIKNLPSI--ISACDGAMVARGDLGAELPIEEVPLLQEEIIRRCRSIHKPVIVATNMLESMIN 380

  Fly   364 F---KRFELHDFLWKV----DAIHIQKSPWCNKYPLIVKKLMPIKDYRVGAVQNKMVLKSILTSY 421
            .   .|.|:.|....|    |||.:.......|:||....:|.....|..|........|..|:|
plant   381 HPTPTRAEVSDIAIAVREGADAIMLSGETAHGKFPLKAVNVMHTVALRTEASLPVRTSASRTTAY 445

  Fly   422 QTIV--------NFIIRTISSIECQAIFLFTTCETASVALS-------------------RIEIY 459
            :..:        :.:..|:||    .:.:||...:.:|.||                   |:.:|
plant   446 KGHMGQMFAFHASIMANTLSS----PLIVFTRTGSMAVLLSHYRPSATIFAFTNQRRIMQRLALY 506

  Fly   460 ---CPVYVMVPLEETDDAETITCKVELARALHL 489
               .|:|    :|.:||||.     ..||:|.|
plant   507 QGVMPIY----MEFSDDAED-----TYARSLKL 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12229	NP_648980.1	pyruv_kin	103..530	CDD:273424	96/465 (21%)
CG12229	NP_648980.1	Pyruvate_Kinase	126..530	CDD:304951	91/442 (21%)
PKp3	NP_564402.1	PLN02623	3..569	CDD:215334	115/553 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870