Protein Alignment CG12229 and PKM

DIOPT Version :9

• Sequence 1: NP_648980.1
• Gene: CG12229 / 39945
• FlyBaseID: FBgn0036723
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_001193725.1
• Gene: PKM / 5315
• HGNCID: 9021
• Length: 605
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 104/477 - (21%)
• Similarity: 187/477 - (39%)
• Gaps: 72/477 - (15%)

  Fly    91 RRMLENGTYTFHVDTVGNKPDELKAILDTMNIAISAHSAERELRLTTGLALEINGECCRVGRLRN 155
            |....:||:.:|.:|:.|           :..|..:.:::..|.....:||:..|...|.|.::.
Human   147 RLNFSHGTHEYHAETIKN-----------VRTATESFASDPILYRPVAVALDTKGPEIRTGLIKG 200

  Fly   156 NCT--VMLARGGVVTLTTDESYRYKGFKEIVYVINLRCYLASVQLG-----DIVMIGREVRGKVV 213
            :.|  |.|.:|..:.:|.|.:|..|..:.|:: ::.:.....|::|     |..:|..:|:.|..
Human   201 SGTAEVELKKGATLKITLDNAYMEKCDENILW-LDYKNICKVVEVGSKIYVDDGLISLQVKQKGA 264

  Fly   214 KTLREALTVMIIDAGLVASYDFIELPRQCHALDPDLYPDLYMKDLEMAASLNANYVVLPKIRCKS 278
                :.|...:.:.|.:.|...:.||..  |:|.....:..::||:.....:.:.|....||..|
Human   265 ----DFLVTEVENGGSLGSKKGVNLPGA--AVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAS 323

  Fly   279 FLRAVRQTL-NSDFNLKLIGMID-FEYVRSNMLDLLGIIKLVDYIWIP--DMFNVNCCVYNYIME 339
            .:..||:.| ....|:|:|..|: .|.||  ..|  .|::..|.|.:.  |: .:........:.
Human   324 DVHEVRKVLGEKGKNIKIISKIENHEGVR--RFD--EILEASDGIMVARGDL-GIEIPAEKVFLA 383

  Fly   340 DVLPISQCQK--KPVI-GTVPLERCSDFK-----RFELHD----FLWKVDAIHIQKSPWCNKYPL 392
            ..:.|.:|.:  |||| .|..||  |..|     |.|..|    .|...|.|.:........|||
Human   384 QKMMIGRCNRAGKPVICATQMLE--SMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPL 446

  Fly   393 IVKKLMPI--KDYRVGAVQNKMVLKSILTSYQTIVNFIIRTISSIE----CQAIFLFTTCETASV 451
            ...::..:  ::........|:..:.:..|..:........:.|:|    |.|..|....|:...
Human   447 EAVRMQHLIAREAEAAMFHRKLFEELVRASSHSTDLMEAMAMGSVEASYKCLAAALIVLTESGRS 511

  Fly   452 A--LSRIEIYCPVYVMVPLEETDDAETITCKVELARALHLRRNMHPVLYTKDLNECSYSPIEFGV 514
            |  ::|.....|:.            .:|...:.||..||.|.:.|||....:.|.....::..|
Human   512 AHQVARYRPRAPII------------AVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRV 564

  Fly   515 DFM----RKKGCLEVGDFVVTL 532
            :|.    :.:|..:.||.|:.|
Human   565 NFAMNVGKARGFFKKGDVVIVL 586

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12229	NP_648980.1	pyruv_kin	103..530	CDD:273424	98/461 (21%)
		Pyruvate_Kinase	126..530	CDD:304951	95/438 (22%)
PKM	NP_001193725.1	Pyruvate_Kinase	116..604	CDD:238178	104/477 (22%)
		pyruv_kin	117..601	CDD:273424	104/477 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.870