Protein Alignment CG12229 and CG11249

DIOPT Version :10

• Sequence 1: NP_648980.1
• Gene: CG12229 / 39945
• FlyBaseID: FBgn0036723
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_649346.1
• Gene: CG11249 / 40409
• FlyBaseID: FBgn0037115
• Length: 642
• Species: Drosophila melanogaster
• Alignment Length: 525
• Identity: 105/525 - (20%)
• Similarity: 188/525 - (35%)
• Gaps: 126/525 - (24%)

  Fly    14 SQTGEDQGEEEEQPED-------ENRLEKFTVRLNGQHDLEQRLKDFK-----AACEAHEKHARR 66
            |...|::.:.||..||       |:|...|             .|||:     ...:.:|
  Fly    88 SSASEEELDFEELSEDPCNISFEEDRWHGF-------------FKDFQILTTPVGTDPNE----- 134

  Fly    67 RKRKRYYHLGLVAKLVTETTHD-ELRRMLENGTYTFHVDTV-GNKPDELKAILDTMNIAISAHSA 129
             .||       ..:|.:.|..| |::..|..|...|.|:.. |.:.|....|:......||. |.
  Fly   135 -NRK-------CVELTSMTNCDLEIKHHLLGGVRCFMVNLFEGTQHDNQSLIVKLREAEISV-SK 190

  Fly   130 ERELRLTTGLALEIN------GECCRVGRLRNNCTVMLARGGVVTLTTDESYRYKGFKEIVYVIN 188
            |....:|:.:.::|:      |......|......|.|.:|..|.||.|..|..:...:::|| |
  Fly   191 ELGFPVTSSVMVKISPRHQFTGGFSTQFRQEGKKCVELVQGQKVILTVDRQYSDRSNADVIYV-N 254

  Fly   189 LRCYLASVQLGDIVMIGREVRGKVVKTLREALTVMIIDAGLVASYDFIELPRQCHALDPDLYPDL 253
            .|..:..|...|.::||.:::..|.....:.|...:...|::.::..:..|.:|...... |.:|
  Fly   255 ARFLIVDVHPLDFILIGEDIQLMVRSIHADHLKGCVARGGMLYAHMPVLFPARCRRFRIS-YEEL 318

  Fly   254 YMKDLEMAASLNANYVV-----LPK-----------IRCKSFLRAVRQTLNSDFNLKLIGMIDFE 302
              :||..|..:..|.||     .||           :.|.......|..||.....|  |.:::.
  Fly   319 --EDLTFAREVGLNVVVSHIVGTPKYVDNLEHAMSAMHCDGMRLYARVVLNEVQGCK--GELNWA 379

  Fly   303 YVRSNMLDLLGIIKLVDYIWIPDMFNVNCCVYNYIMEDVLPISQC-------QKKPVIGTVPLER 360
            ..|.:..    :::|.:...:||:.::  |          |.::|       .|||:|
  Fly   380 IKRYDGF----LVELAEPATVPDIMHL--C----------PDAECFMQLTYAAKKPII------- 421

  Fly   361 CSDFKRFELHDFLWKVDAIHIQKSPWCNKYPLIVKKLMPIKDYRVGAVQNKMVLKSIL------- 418
               |....|.:...:||..|...:.:   ||   .|.:.......|.:..:::..:|.
  Fly   422 ---FDPRLLDEQKLRVDPAHYYYTFY---YP---DKYVTTCPQPKGTIYFRLLQSAIFEQISPTA 477

  Fly   419 ---TSY----QTIVNFIIRTI--SSIECQAIFLFTTCETASVA--LSRIEIYCPVYVMVPLEETD 472
               |.|    .|..:.:.|::  :|||..|:.:.....|..:.  :|....:.|:..:..:...:
  Fly   478 LANTPYCDRSHTGADSLARSVVTASIEVHAVAIVVIGVTTRMVQKISHFRPHAPILFVSHMRSAE 542

  Fly   473 DAETI 477
            |..:|
  Fly   543 DYVSI 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12229	NP_648980.1	Pyruvate_Kinase	126..530	CDD:453956	77/399 (19%)
CG11249	NP_649346.1	Pyruvate_Kinase	158..>332	CDD:453956	41/178 (23%)
		PK_C	492..594	CDD:460738	10/56 (18%)