DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12229 and pyk1

DIOPT Version :9

Sequence 1:	NP_648980.1	Gene:	CG12229 / 39945	FlyBaseID:	FBgn0036723	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_594346.1	Gene:	pyk1 / 2543557	PomBaseID:	SPAC4H3.10c	Length:	509	Species:	Schizosaccharomyces pombe

Alignment Length:	482	Identity:	97/482 - (20%)
Similarity:	179/482 - (37%)	Gaps:	83/482 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 LRRMLENGTYTFHVDTVGNKPDELKAILDTMNIAISAHSAERELRLTTGLALEINGECCRVGRLR 154
            :|....:|:|.:|           ::::|....|    ||...| ....:||:..|...|.|...
pombe    55 VRMNFSHGSYEYH-----------QSVIDNARKA----SATNPL-FPLAIALDTKGPEIRTGLTV 103

  Fly   155 NNCTVMLARGGVVTLTTDESYRYKGFKEIVYVINLRCYLASVQLGDIVMIGREVRGKVV--KTLR 217
            ......::.|..:..|||::|..|...:::| |:.:.....:|.|.|:.:...:....|  |...
pombe   104 GGTDYPISSGHEMIFTTDDAYAEKCNDKVMY-IDYKNITKVIQPGRIIYVDDGILSFTVIEKVDD 167

  Fly   218 EALTVMIIDAGLVASYDFIELPRQCHALDPDLYPDLYMK---DLEMAASLNANYVVLPKIRCKSF 279
            :.|.|.:.:.|.::|...:.||:    .|.|| |.|..|   ||........:.:....||....
pombe   168 KNLKVRVNNNGKISSKKGVNLPK----TDVDL-PALSEKDKADLRFGVKNGVDMIFASFIRRAED 227

  Fly   280 LRAVRQTLNSD-FNLKLIGMIDFEYVRSNMLDLLGIIKLVDYIWIP--DMFNVNCCVYNYIMEDV 341
            :..:|:.|..: .|:|:|..|:.:...:|...:|.:   .|.|.:.  |: .:........:...
pombe   228 VIHIREVLGEEGKNIKIICKIENQQGVNNFDSILDV---TDGIMVARGDL-GIEIPASQVFVAQK 288

  Fly   342 LPISQCQ--KKPVIGTVPLERCSDFK----RFELHD----FLWKVDAIHIQKSPWCNKYPLIVKK 396
            :.|::|.  .|||.....:.....:.    |.|:.|    .|...|.:.:........||:....
pombe   289 MMIAKCNIAGKPVACATQMLESMTYNPRPTRAEVSDVGNAVLDGADLVMLSGETTKGSYPVEAVT 353

  Fly   397 LMPIKDYRVGAVQNKMVLKSIL---TSYQTIVNFIIRTISSIECQAIFLFTTCETASVALSRIEI 458
            .|         .:...|.::.:   :.||.:...:.|   .:||       ..||.:||.....|
pombe   354 YM---------AETARVAEASIPYGSLYQEMFGLVRR---PLEC-------ATETTAVAAIGASI 399

  Fly   459 YCPVYVMVPLEETDDAETITCKV-------------ELARALHLRRNMHPVLYTK----DLNECS 506
            ......:|.|..:.:...:..|.             :.||..||.|.::||:|.|    |..:..
pombe   400 ESDAKAIVVLSTSGNTARLCSKYRPSIPIVMVTRCPQRARQSHLNRGVYPVIYEKEPLSDWQKDV 464

  Fly   507 YSPIEFGVDFMRKKGCLEVGDFVVTLE 533
            .:.:.:|.....|...|:.||.::.|:
pombe   465 DARVAYGCQQAYKMNILKKGDKIIVLQ 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12229	NP_648980.1	pyruv_kin	103..530	CDD:273424	92/464 (20%)
CG12229	NP_648980.1	Pyruvate_Kinase	126..530	CDD:304951	90/441 (20%)
pyk1	NP_594346.1	Pyruvate_Kinase	25..508	CDD:238178	97/482 (20%)
pyk1	NP_594346.1	pyruv_kin	26..505	CDD:273424	97/482 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870