Protein Alignment CG12229 and Pkm

DIOPT Version :9

• Sequence 1: NP_648980.1
• Gene: CG12229 / 39945
• FlyBaseID: FBgn0036723
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: XP_011240976.2
• Gene: Pkm / 18746
• MGIID: 97591
• Length: 604
• Species: Mus musculus
• Alignment Length: 478
• Identity: 107/478 - (22%)
• Similarity: 191/478 - (39%)
• Gaps: 74/478 - (15%)

  Fly    91 RRMLENGTYTFHVDTVGNKPDELKAILDTMNIAISAHSAERELRLTTGLALEINGECCRVGRLRN 155
            |....:||:.:|.:|:.|           :..|..:.:::..|.....:||:..|...|.|.::.
Mouse   146 RLNFSHGTHEYHAETIKN-----------VREATESFASDPILYRPVAVALDTKGPEIRTGLIKG 199

  Fly   156 NCT--VMLARGGVVTLTTDESYRYKGFKEIVYVINLRCYLASVQLG-----DIVMIGREVRGKVV 213
            :.|  |.|.:|..:.:|.|.:|..|..:.|:: ::.:.....|::|     |..:|..:|:.|..
Mouse   200 SGTAEVELKKGATLKITLDNAYMEKCDENILW-LDYKNICKVVEVGSKIYVDDGLISLQVKEKGA 263

  Fly   214 KTLREALTVMIIDAGLVASYDFIELPRQCHALDPDLYPDLYMKDLEMAASLNANYVVLPKIRCKS 278
                :.|...:.:.|.:.|...:.||..  |:|.....:..::||:.....:.:.|....||..:
Mouse   264 ----DFLVTEVENGGSLGSKKGVNLPGA--AVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKAA 322

  Fly   279 FLRAVRQTL-NSDFNLKLIGMID-FEYVRSNMLDLLGIIKLVDYIWIP--DMFNVNCCVYNYIME 339
            .:..||:.| ....|:|:|..|: .|.||  ..|  .|::..|.|.:.  |: .:........:.
Mouse   323 DVHEVRKVLGEKGKNIKIISKIENHEGVR--RFD--EILEASDGIMVARGDL-GIEIPAEKVFLA 382

  Fly   340 DVLPISQCQK--KPVI-GTVPLERCSDFK-----RFELHD----FLWKVDAIHIQKSPWCNKYPL 392
            ..:.|.:|.:  |||| .|..||  |..|     |.|..|    .|...|.|.:........|||
Mouse   383 QKMMIGRCNRAGKPVICATQMLE--SMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPL 445

  Fly   393 -IVKKLMPIKDYRVGAVQNKMVLKSI-----LTSYQTIVNFIIRTISSIEC--QAIFLFTTCETA 449
             .|:....|......|:.:..:.:.:     :||..|....:....:|.:|  .||.:.|....:
Mouse   446 EAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEAAAVGAVEASFKCCSGAIIVLTKSGRS 510

  Fly   450 SVALSRIEIYCPVYVMVPLEETDDAETITCKVELARALHLRRNMHPVLYTKD--LNECSYS---P 509
            :..::|.....|:.            .:|...:.||..||.|.:.||| .||  ||..:..   .
Mouse   511 AHQVARYRPRAPII------------AVTRNPQTARQAHLYRGIFPVL-CKDAVLNAWAEDVDLR 562

  Fly   510 IEFGVDFMRKKGCLEVGDFVVTL 532
            :...:|..:.:|..:.||.|:.|
Mouse   563 VNLAMDVGKARGFFKKGDVVIVL 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12229	NP_648980.1	pyruv_kin	103..530	CDD:273424	101/462 (22%)
		Pyruvate_Kinase	126..530	CDD:304951	98/439 (22%)
Pkm	XP_011240976.2	Pyruvate_Kinase	115..603	CDD:238178	107/478 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0469
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.870