DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12229 and pyk-1

DIOPT Version :9

Sequence 1:	NP_648980.1	Gene:	CG12229 / 39945	FlyBaseID:	FBgn0036723	Length:	571	Species:	Drosophila melanogaster
Sequence 2:	NP_001379495.1	Gene:	pyk-1 / 172744	WormBaseID:	WBGene00009126	Length:	913	Species:	Caenorhabditis elegans

Alignment Length:	547	Identity:	120/547 - (21%)
Similarity:	204/547 - (37%)	Gaps:	114/547 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 EQRLKDFKAACEAHEKHARRRKRKRYYHL----GLVAKLVTETTHDELRRML------------E 95
            ||:|....|.  .|.:|..|...:...||    |::..:.......|:.:.|            .
Worm   401 EQKLAAVPAT--THMEHLCRLDIREAPHLVRQTGIICTIGPACASVEMLQKLILNGMNIARLNFS 463

  Fly    96 NGTYTFHVDTVGNKPDELKAILDTMNIAISAHSAERELRLTTGLALEINGECCRVGRLRNNCT-- 158
            :|::.:|..|:.|           :..|..:.|.:|.:    |:||:..|...|.|.|....:
Worm   464 HGSHEYHAGTIAN-----------VREAADSFSDKRVI----GIALDTKGPEIRTGLLAGGASAE 513

  Fly   159 VMLARGGVVTLTTDESYRYKG--------FKEIVYVINL--RCYLASVQLGDIVMIGREVRGKVV 213
            :.||||..:.||||..:...|        :|.|..|:::  |.|:..   |.|.:|..|::
Worm   514 IELARGASIRLTTDPHFSESGTAVNLFVDYKNIAKVLSVGSRVYIDD---GLISLIVEELQ---- 571

  Fly   214 KTLREALTVMIIDAGLVASYDFIELPRQCHALDPDLYPDLYMKDLEMAASLNANYVVLPKIRCKS 278
               .:|:...:.:.|::.|...:.||..  .:|.....:...|||:.......:.:....||...
Worm   572 ---TDAVICSVENGGMLGSRKGVNLPGT--IVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAE 631

  Fly   279 FLRAVRQTL-NSDFNLKLIGMIDFEYVRSNMLDLLGIIKLVDYIWIP--DMFNVNCCVYNYIMED 340
            .:|.:|:.| .....:|:|..|:.:....|..:   ||...|.:.:.  |: .:........:..
Worm   632 GIRTIRKVLGEKGKKIKIIAKIENQEGVDNADE---IISESDGVMVARGDL-GIEIPAEKVFLAQ 692

  Fly   341 VLPISQCQK--KPVI-GTVPLERC-----------SDFKRFELHDFLWKVDAIHIQKSPWCNKYP 391
            .:.||:|.:  |||| .|..||..           ||.....|..    .|.:.:.......:||
Worm   693 KMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDG----ADCVMLSGETAKGEYP 753

  Fly   392 LIVKKLMP-IKDYRVGAVQNKMVLKSILTSYQ-------TIVNFIIRTISSIECQAIFLFTTCET 448
            :...|:|. |......||.::.:...:|.:.|       ||........:|....||.|.||...
Worm   754 VDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPTDMSHTIAIAATSAAASCHASAILLITTTGR 818

  Fly   449 ASVALSRIEIYCPVYVMVPLEETDDAETITCKVELARALHLRRNMHPVLY--------TKDLNEC 505
            :::..||.:...|:.            ||:..|.:.|.|||.|.:.||.|        ..|::..
Worm   819 SAIQCSRYKPAVPIL------------TISRDVAVCRQLHLYRGVFPVHYPAERAADWPTDVDNR 871

  Fly   506 SYSPIEFGVDFMRKKGCLEVGDFVVTL 532
            ....|..|.|    :|.:..|||:|.:
Worm   872 INHAIAIGKD----RGFIHKGDFLVVV 894

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12229	NP_648980.1	pyruv_kin	103..530	CDD:273424	105/471 (22%)
CG12229	NP_648980.1	Pyruvate_Kinase	126..530	CDD:304951	102/448 (23%)
pyk-1	NP_001379495.1	Pyruvate_Kinase	429..912	CDD:238178	111/517 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11817
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010