Protein Alignment CG12229 and pyk-1

DIOPT Version :10

• Sequence 1: NP_648980.1
• Gene: CG12229 / 39945
• FlyBaseID: FBgn0036723
• Length: 571
• Species: Drosophila melanogaster
• Sequence 2: NP_001379495.1
• Gene: pyk-1 / 172744
• WormBaseID: WBGene00009126
• Length: 913
• Species: Caenorhabditis elegans
• Alignment Length: 547
• Identity: 120/547 - (21%)
• Similarity: 204/547 - (37%)
• Gaps: 114/547 - (20%)

  Fly    47 EQRLKDFKAACEAHEKHARRRKRKRYYHL----GLVAKLVTETTHDELRRML------------E 95
            ||:|....|.  .|.:|..|...:...||    |::..:.......|:.:.|            .
 Worm   401 EQKLAAVPAT--THMEHLCRLDIREAPHLVRQTGIICTIGPACASVEMLQKLILNGMNIARLNFS 463

  Fly    96 NGTYTFHVDTVGNKPDELKAILDTMNIAISAHSAERELRLTTGLALEINGECCRVGRLRNNCT-- 158
            :|::.:|..|:.|           :..|..:.|.:|.:    |:||:..|...|.|.|....:
 Worm   464 HGSHEYHAGTIAN-----------VREAADSFSDKRVI----GIALDTKGPEIRTGLLAGGASAE 513

  Fly   159 VMLARGGVVTLTTDESYRYKG--------FKEIVYVINL--RCYLASVQLGDIVMIGREVRGKVV 213
            :.||||..:.||||..:...|        :|.|..|:::  |.|:..   |.|.:|..|::
 Worm   514 IELARGASIRLTTDPHFSESGTAVNLFVDYKNIAKVLSVGSRVYIDD---GLISLIVEELQ---- 571

  Fly   214 KTLREALTVMIIDAGLVASYDFIELPRQCHALDPDLYPDLYMKDLEMAASLNANYVVLPKIRCKS 278
               .:|:...:.:.|::.|...:.||..  .:|.....:...|||:.......:.:....||...
 Worm   572 ---TDAVICSVENGGMLGSRKGVNLPGT--IVDLPAVSEKDCKDLQFGVEQGVDIIFASFIRNAE 631

  Fly   279 FLRAVRQTL-NSDFNLKLIGMIDFEYVRSNMLDLLGIIKLVDYIWIP--DMFNVNCCVYNYIMED 340
            .:|.:|:.| .....:|:|..|:.:....|..:   ||...|.:.:.  |: .:........:..
 Worm   632 GIRTIRKVLGEKGKKIKIIAKIENQEGVDNADE---IISESDGVMVARGDL-GIEIPAEKVFLAQ 692

  Fly   341 VLPISQCQK--KPVI-GTVPLERC-----------SDFKRFELHDFLWKVDAIHIQKSPWCNKYP 391
            .:.||:|.:  |||| .|..||..           ||.....|..    .|.:.:.......:||
 Worm   693 KMLISKCNRAGKPVICATQMLESMVHKPRPTRAEGSDVANAVLDG----ADCVMLSGETAKGEYP 753

  Fly   392 LIVKKLMP-IKDYRVGAVQNKMVLKSILTSYQ-------TIVNFIIRTISSIECQAIFLFTTCET 448
            :...|:|. |......||.::.:...:|.:.|       ||........:|....||.|.||...
 Worm   754 VDALKIMHYICKEAEAAVYHRRLFDELLQNTQKPTDMSHTIAIAATSAAASCHASAILLITTTGR 818

  Fly   449 ASVALSRIEIYCPVYVMVPLEETDDAETITCKVELARALHLRRNMHPVLY--------TKDLNEC 505
            :::..||.:...|:.            ||:..|.:.|.|||.|.:.||.|        ..|::..
 Worm   819 SAIQCSRYKPAVPIL------------TISRDVAVCRQLHLYRGVFPVHYPAERAADWPTDVDNR 871

  Fly   506 SYSPIEFGVDFMRKKGCLEVGDFVVTL 532
            ....|..|.|    :|.:..|||:|.:
 Worm   872 INHAIAIGKD----RGFIHKGDFLVVV 894

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12229	NP_648980.1	Pyruvate_Kinase	126..530	CDD:453956	102/448 (23%)
pyk-1	NP_001379495.1	Pyruvate_Kinase	429..912	CDD:238178	111/517 (21%)