DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment frc and SLC35E4

DIOPT Version :9

Sequence 1:	NP_001137962.1	Gene:	frc / 39943	FlyBaseID:	FBgn0042641	Length:	373	Species:	Drosophila melanogaster
Sequence 2:	NP_001001479.1	Gene:	SLC35E4 / 339665	HGNCID:	17058	Length:	350	Species:	Homo sapiens

Alignment Length:	293	Identity:	69/293 - (23%)
Similarity:	117/293 - (39%)	Gaps:	29/293 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 SALFYGLSSFMITVVNKTVLTSYHFPSFLFLSLGQLTASIVVLGMGKRLKLVNFPPLQRNTFAKI 130
            :||.:.|:...::.:||.:.|.:.|...|.||...:..:.:....|.|      .|:...|..::
Human    52 AALVWLLAGASMSSLNKWIFTVHGFGRPLLLSALHMLVAALACHRGAR------RPMPGGTRCRV 110

  Fly   131 FPLPLIFLGNMMFGLGGTKTLSLPMFAALRRFSILMTMLLELKILGLRPSNAVQVSVYAMIGGAL 195
            ..|.|.|..:|..|..|.:.:.|.:...:...:.|.|:.|...:|| |..:.:|:   |.:|...
Human   111 LLLSLTFGTSMACGNVGLRAVPLDLAQLVTTTTPLFTLALSALLLG-RRHHPLQL---AAMGPLC 171

  Fly   196 LAASDDLSFNMR----GYIYVMITNALTASNGVYVKKKLDTSEIGKYGLMYYNSL--FMFLPALA 254
            |.|:..|:...|    |..:::....|.....|.....|....:....|:|..||  |..|...|
Human   172 LGAACSLAGEFRTPPTGCGFLLAATCLRGLKSVQQSALLQEERLDAVTLLYATSLPSFCLLAGAA 236

  Fly   255 LNYVTGNLDQALNFEQWNDSVFVVQFLLSCVMGFILSYSTILCTQFNSALTTTIVGCLKNICVTY 319
            |....|.......    .||......||||::..:.:.::.......||||..::|.|     |.
Human   237 LVLEAGVAPPPTA----GDSRLWACILLSCLLSVLYNLASFSLLALTSALTVHVLGNL-----TV 292

  Fly   320 LGMFIGGDYVF----SWLNCIGINISVLASLLY 348
            :|..|....:|    |.|:.:||.:::....||
Human   293 VGNLILSRLLFGSRLSALSYVGIALTLSGMFLY 325

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
frc	NP_001137962.1	TPT	67..348	CDD:281186	67/290 (23%)
SLC35E4	NP_001001479.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..42
		EamA	51..178	CDD:304911	32/135 (24%)
		TPT	54..325	CDD:281186	66/289 (23%)
		EamA	188..324	CDD:279264	33/144 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156702
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840