DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec3 and SEC3

DIOPT Version :9

Sequence 1:	NP_648976.2	Gene:	Sec3 / 39940	FlyBaseID:	FBgn0266669	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_010924.1	Gene:	SEC3 / 856726	SGDID:	S000000810	Length:	1336	Species:	Saccharomyces cerevisiae

Alignment Length:	804	Identity:	141/804 - (17%)
Similarity:	303/804 - (37%)	Gaps:	158/804 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 EEDEEEEA-----QEFTALTDKEANELGKLFSECDFAIK-DAEQFIEQLSRELHDLDGANMQSVL 225
            ||:.|.||     :|...:.:.:...|.::.::.:::|: ||:..||::...|.:.:....|::|
Yeast   601 EENNESEALIESKEEIKTMENIDDEVLLEILTDINWSIEDDADSMIERIDLRLAETEYLFNQNLL 665

  Fly   226 ASEQKVLKMMEHIDNAISEADKFENRLDSYEDILGHVKETMEKIGGKNAMIEIANNNNIKLMKEL 290
            :.::....:..:.|....|..:....|..:...:.:....:|.:..::..:::.:.|...|...|
Yeast   666 SLQKIGPNIRPYEDKVNDECHRIIPTLSLFLMEMSNFSNDIENVESQDNGLQVESANKKLLWNTL 730

  Fly   291 NKVISQLDLPH-SQQQALD----EPDLKTANGRKAAIAAAQCLQQAMNSD---IDPALLRLEAVQ 347
            ::::..:.|.. |..|.|:    |.:|.....:...:..|   .||:.||   ::..|..:..::
Yeast   731 DELLKTVSLDEISLNQLLECPIREKNLPWMENQLNLLLKA---FQAIGSDGNEVEYNLREISGLK 792

  Fly   348 DQRKRFEKWKQKFSATVSRFMNNLFIHL-GNEIGDMQVTSTELTLPNHSNVHRELTP---YTELM 408
            .:.:.:||..:.|...:...|...|.:: |.:|             :|..:.|.||.   ::.|:
Yeast   793 QRLQFYEKVTKIFLNRIVEEMQKKFSNIRGQDI-------------SHDQMIRILTTLLIFSPLI 844

  Fly   409 HWTKAMDRKTYDGLMRVYTASLSKIYDRDVRNFFNLAKIQVTEKLRNSREDLDMSTSSRKSAVST 473
            .:.|.:.:|:|..::..:..|:..:|                           |...::|  :|.
Yeast   845 LFCKEISQKSYQAIVENWNVSIQPVY---------------------------MELWTKK--ISQ 880

  Fly   474 IPYGTLGINRDQWGPGVETADRMRFDALLEKVLAELEPIALQEQLFCINFFQMDVISPTTKN--- 535
            :             .|::|.|....:..|.::|.|.:....:.:...||        |..||
Yeast   881 L-------------QGIDTNDEKMNELSLSQLLNEWDTFRKERKTNDIN--------PVFKNSFS 924

  Fly   536 --TQTTLEMEKAVDMTQSIISGAVSPSG---------------------DGVPQKRIDRQINEDV 577
              |:....|.:...:.|:.:......|.                     |.|...:.||:.....
Yeast   925 LLTECLQTMRQECIVYQNFVEVFFHISSKHNFEEYIKHFNDPDAPPILLDTVKVMQSDREAAVIE 989

  Fly   578 RKLMMGLFGCLEPELVSFIQSFERVDSFYSLYVFVRLTQHVMSAQDT-HSFLSMTFASALVQVKR 641
            .:|:..:|..:...|.|:.....:.:...:..:...|...:.|.:.: |.||.........|:|:
Yeast   990 TQLVSRIFQPIVTRLSSYFVELVKAEPTVAPALTFYLENEIKSLESSNHEFLLSAVTRMYTQIKQ 1054

  Fly   642 SFDRFMQNQLLSIREAKLHKRSKAILPYVENFENFAQTAEGIFRKSDRRTDM---EKWY--LQLV 701
            .:...::.|:|..........:..|||.:.:.....:.:|.:|:.:.|..|:   ::.|  ::|:
Yeast  1055 VWSDNVEEQVLHFERISNATTNGEILPGILDLPVGLKNSEDLFQFAKRSMDIKDTDEGYESIELM 1119

  Fly   702 NAIFEGI-----------QLHSQEHPKTPVQVVRMENYHHMYALLA------------QLKVPGL 743
            |:.|..:           :::|..:|..........:|....:||.            .....|:
Yeast  1120 NSSFRKLSIAATRSITHKEVNSSINPNLSDTAALNNDYMETISLLVNSNWLTEMLSMLNFNKDGI 1184

  Fly   744 -DALKKEAKKCYNDALKAYVTQYFGRPLEKLNQFFEGVQ--LKVAQGVKETEISYQMAFSKQELR 805
             |...:..||.::...::|.:......:.||..|..||.  ::....|..|..|...|:|:|.|.
Yeast  1185 FDTSLQNVKKVFDVEKESYASFLLRDTMPKLTAFVYGVSNIIENTNNVNMTNPSRWAAYSRQNLE 1249

  Fly   806 KVIAQYPAREVKKGLENLYKKVEKHL-----SEEEN-----LLQVVWHAMQEEFIAQYNYLEERI 860
            .::..|.:.|:    |.|.|::..|:     ..:||     |...:|..:|.:.::.|..|...|
Yeast  1250 NILLAYTSHEI----ETLVKRLHTHMVNDFGYHQENAINNVLCDKLWSCIQGQTVSLYLKLYTVI 1310

  Fly   861 QKCYAGAMINLEFNIQDILAFFSD 884
            .|.|.|.  |:.|...||::.|.:
Yeast  1311 DKHYRGT--NIRFTKNDIISAFEE 1332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec3	NP_648976.2	PH-EXOC1	9..126	CDD:270202
Sec3	NP_648976.2	Sec3_C	200..866	CDD:286804	127/746 (17%)
SEC3	NP_010924.1	PH_Sec3	82..232	CDD:270125
		PTZ00121	<283..478	CDD:173412
		SMC_N	<348..629	CDD:308206	7/27 (26%)
		ARGLU	<358..444	CDD:405931
		Sec3_C	640..1316	CDD:418729	127/745 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343011
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102748
Panther	1	1.100	-	-	LDO	PTHR16092
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930