DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec3 and Exoc1

DIOPT Version :9

Sequence 1:	NP_648976.2	Gene:	Sec3 / 39940	FlyBaseID:	FBgn0266669	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	XP_036021371.1	Gene:	Exoc1 / 69940	MGIID:	2445020	Length:	923	Species:	Mus musculus

Alignment Length:	949	Identity:	378/949 - (39%)
Similarity:	566/949 - (59%)	Gaps:	92/949 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MANIKHTLQKELFLASGERLLSVVTVVKK-KDKKPCYLC-VVTTAPPVPVVTLCLIKQSEQREGE 69
            |..|||.||:::|..:.|||||:|.|.|. |.||.|:|| .|||..||.|.   ::|..:..:|:
Mouse     1 MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVK---VVKVKKSDKGD 62

  Fly    70 -YKRKRSWQLDEIKWVDGRNEQFETHEFDLQLEKLYKWYALNPHERQNFLAVLNRQIQKSVRGQR 133
             |||:.:|.|.::..||.::...|..||||..||:|||.|.:..|:..|::.:.:..|:.:| ::
Mouse    63 FYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKVYKWVASSTAEKNAFISCIWKLNQRYLR-KK 126

  Fly   134 AEFRNVPAAWLSEKSPEKVALG-RAVQKTQHMDDEEDEEEEAQEFTALTDKEANELGKLFSECDF 197
            .:|.||.:..|..|..||...| ::|...::......:||...|:..|..:|..::..:...|:.
Mouse   127 IDFVNVSSQLLEGKVKEKAYAGSQSVPSGENQSVAGGDEEAVDEYQELNAREEQDIEIMMEGCEC 191

  Fly   198 AIKDAEQFIEQLSRELHDLDGANMQSVLASEQKVLKMMEHIDNAISEADKFENRLDSYEDILGHV 262
            ||.:||.|.|:|||||..|||||:||::|||::|..:|:.:|.|::|.|:.|.:|.|||::|..|
Mouse   192 AISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNTLMQLLDEALTEVDQIELKLSSYEEMLQSV 256

  Fly   263 KETMEKIGGKNAMIEIANNNNIKLMKELNKVISQLDLPHSQQQALDEPDLKTANGRKAAIAAAQC 327
            ||.|::|...|.:|.::|.||:||:.|:..:::.:||.....:||.|.||.::.|.:|...||..
Mouse   257 KEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLVSSRGIEACTNAADA 321

  Fly   328 LQQAMNSDIDPALLRLEAVQDQRKRFEKWKQKFSATVSRFMNNLFI--------HLGNEIGDMQV 384
            |.|.||..:.|....|.||:.|::||...::.|:..::..:||:|:        .|.|....:.|
Mouse   322 LLQCMNVALRPGHDMLLAVKQQQQRFSDLREHFARRLASHLNNVFVQQFTQALLQLYNRSYFLSV 386

  Fly   385 T-----------STELTLPNHSNVHRELTPYTELMHWTKAMDRKTYDGLMRVYTASLSKIYDRDV 438
            .           |.|||||||...||:|..|.:||.|.|:.|...|:||.:.|...||::|:|::
Mouse   387 PGHDQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYEREI 451

  Fly   439 RNFFNLAKI-----------------------QVTEKLRNSREDLDMSTSS------------RK 468
            ::||.:||:                       |.||.|..|...|..||||            |.
Mouse   452 KDFFEVAKMKMTGTSKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQSSGSRRS 516

  Fly   469 SAVSTIPYGTLGINRDQWGPGVETADRMRFDALLEKVLAELEPIALQEQLFCINFFQMDVISPTT 533
            .:.|.:..|.:..:      .::.|||.:||.:.|:||:||||:.|.||.|...||::.
Mouse   517 QSSSLLDMGNMSAS------DLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQ------ 569

  Fly   534 KNTQTTLEMEKAVDMTQSII-----SGAVSPSGDGVPQKRIDRQINEDVRKLMMGLFGCLEPELV 593
            ::...:..|.:|.|:....:     ||.:.|    |..::      :.:|::|:.:|.|:||||.
Mouse   570 QHQNMSASMTEAEDLDGGSLLRQHSSGTLLP----VSSEK------DMIRQMMIKIFRCIEPELN 624

  Fly   594 SFIQSFERVDSFYSLYVFVRLTQHVMSAQ--DTHSFLSMTFASALVQVKRSFDRFMQNQLLSIRE 656
            :.|...::||||.|||:.|:::.||.:||  |..||||.|..:.||.|||:||:.:.||:..:.|
Mouse   625 NLIALGDKVDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEE 689

  Fly   657 AKLHKRSK-AILPYVENFENFAQTAEGIFRKSDRRTDMEKWYLQLVNAIFEGIQLHSQEHPKTPV 720
            .|:.|:|| .|||:|..||.||..||.||:.::||.|::|.|.:|:..:|..::..:.|..|||.
Mouse   690 VKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFINVEKVANESQKTPR 754

  Fly   721 QVVRMENYHHMYALLAQLKVPGLDALKKEAKKCYNDALKAYVTQYFGRPLEKLNQFFEGVQLKVA 785
            .||.|||:||::|.|::||:..|:|.|||||:.|.|.|::||....|:||||||.|||||:.:||
Mouse   755 DVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNHFFEGVEARVA 819

  Fly   786 QGVKETEISYQMAFSKQELRKVIAQYPAREVKKGLENLYKKVEKHLSEEENLLQVVWHAMQEEFI 850
            ||::|.|:|||:||:||||||||.:||.:||||||:||||||:|||.|||||||||||:||:|||
Mouse   820 QGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEENLLQVVWHSMQDEFI 884

  Fly   851 AQYNYLEERIQKCYAGAMINLEFNIQDILAFFSDIARSH 889
            .||.:.|..|.:||.|:.:.:||.|||||.:.|.||:||
Mouse   885 RQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec3	NP_648976.2	PH-EXOC1	9..126	CDD:270202	48/119 (40%)
Sec3	NP_648976.2	Sec3_C	200..866	CDD:286804	297/727 (41%)
Exoc1	XP_036021371.1	PH-EXOC1	3..120	CDD:270202	48/119 (40%)
Exoc1	XP_036021371.1	Sec3_C	195..900	CDD:401638	297/726 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831195
Domainoid	1	1.000	529	1.000	Domainoid score	I291
eggNOG	1	0.900	-	-		E1_KOG2148
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41241
Inparanoid	1	1.050	646	1.000	Inparanoid score	I795
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55676
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005025
OrthoInspector	1	1.000	-	-		oto92892
orthoMCL	1	0.900	-	-		OOG6_102748
Panther	1	1.100	-	-	O	PTHR16092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6519
SonicParanoid	1	1.000	-	-		X4672
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790