DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec3 and EXOC1

DIOPT Version :9

Sequence 1:	NP_648976.2	Gene:	Sec3 / 39940	FlyBaseID:	FBgn0266669	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	XP_005265804.1	Gene:	EXOC1 / 55763	HGNCID:	30380	Length:	912	Species:	Homo sapiens

Alignment Length:	960	Identity:	380/960 - (39%)
Similarity:	557/960 - (58%)	Gaps:	125/960 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MANIKHTLQKELFLASGERLLSVVTVVKK-KDKKPCYLC-VVTTAPPVPVVTLCLIKQSEQREGE 69
            |..|||.||:::|..:.|||||:|.|.|. |.||.|:|| .|||..||.|.   ::|..:..:|:
Human     1 MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVK---VVKVKKSDKGD 62

  Fly    70 -YKRKRSWQLDEIKWVDGRNEQFETHEFDLQLEKLYKWYALNPHERQNFLAVLNRQIQKSVRGQR 133
             |||:.:|.|.::..||.::...|..||||..||:|||.|.:..|:..|::.:.:..|:.:| ::
Human    63 FYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQRYLR-KK 126

  Fly   134 AEFRNVPAAWLSEKSP----EKVALGRAVQKTQHMDDEEDEEEEAQEFTALTDKEANELGKLFSE 194
            .:|.||.:..|.|..|    :.|..|              :||...|:..|..:|..::..:...
Human   127 IDFVNVSSQLLEESVPSGENQSVTGG--------------DEEVVDEYQELNAREEQDIEIMMEG 177

  Fly   195 CDFAIKDAEQFIEQLSRELHDLDGANMQSVLASEQKVLKMMEHIDNAISEADKFENRLDSYEDIL 259
            |::||.:||.|.|:|||||..|||||:||::|||::|..:|:.:|.|:.|.|:.|.:|.|||::|
Human   178 CEYAISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEEML 242

  Fly   260 GHVKETMEKIGGKNAMIEIANNNNIKLMKELNKVISQLDLPHSQQQALDEPDLKTANGRKAAIAA 324
            ..|||.|::|...|.:|.::|.||:||:.|:..:::.:||.....:||.|.||.::.|.:|...|
Human   243 QSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRGIEACTNA 307

  Fly   325 AQCLQQAMNSDIDPALLRLEAVQDQRKRFEKWKQKFSATVSRFMNNLFI--------HLGNEIGD 381
            |..|.|.||..:.|....|.||:.|::||...::.|:..::..:||:|:        .|.|....
Human   308 ADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQFTQALLQLYNRSYF 372

  Fly   382 MQVT-----------STELTLPNHSNVHRELTPYTELMHWTKAMDRKTYDGLMRVYTASLSKIYD 435
            :.|.           |.|||||||...||:|..|.:||.|.|:.|...|:||.:.|...||::|:
Human   373 LSVPGHDQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYE 437

  Fly   436 RDVRNFFNLAKI-----------------------QVTEKLRNSREDLDMSTSS----------- 466
            |::::||.:|||                       |.||.|..|...|..||||
Human   438 REIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQSSGN 502

  Fly   467 -RKSAVSTIPYGTLGINRDQWGPGVETADRMRFDALLEKVLAELEPIALQEQLFCINFF--QMDV 528
             |..:.|.:..|.:..:      .::.|||.:||.:.|:||:||||:.|.||.|...||  |...
Human   503 RRSQSSSLLDMGNMSAS------DLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQQHQ 561

  Fly   529 ISPTTKNTQTTLEMEKAVDMTQSIISGAVSPSGDGVPQKRIDRQIN-----------EDVRKLMM 582
            ..|.|        |.:|.|:....:|                ||.|           :.:|::|:
Human   562 SMPGT--------MAEAEDLDGGTLS----------------RQHNCGTPLPVSSEKDMIRQMMI 602

  Fly   583 GLFGCLEPELVSFIQSFERVDSFYSLYVFVRLTQHVMSAQ--DTHSFLSMTFASALVQVKRSFDR 645
            .:|.|:||||.:.|...:::|||.|||:.|:::.||.:||  |..||||.|..:.||.|||:||:
Human   603 KIFRCIEPELNNLIALGDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDK 667

  Fly   646 FMQNQLLSIREAKLHKRSK-AILPYVENFENFAQTAEGIFRKSDRRTDMEKWYLQLVNAIFEGIQ 709
            .:.||:..:.|.|:.|:|| .|||:|..||.||..||.||:.::||.|::|.|.:|:..:|..::
Human   668 CISNQIRQMEEVKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVE 732

  Fly   710 LHSQEHPKTPVQVVRMENYHHMYALLAQLKVPGLDALKKEAKKCYNDALKAYVTQYFGRPLEKLN 774
            ..:.|..|||..||.|||:||::|.|::||:..|:|.|||||:.|.|.|::||....|:||||||
Human   733 KVANESQKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLN 797

  Fly   775 QFFEGVQLKVAQGVKETEISYQMAFSKQELRKVIAQYPAREVKKGLENLYKKVEKHLSEEENLLQ 839
            .|||||:.:||||::|.|:|||:||:||||||||.:||.:||||||:||||||:|||.|||||||
Human   798 HFFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEENLLQ 862

  Fly   840 VVWHAMQEEFIAQYNYLEERIQKCYAGAMINLEFNIQDILAFFSDIARSH 889
            ||||:||:|||.||.:.|..|.:||.|:.:.:||.|||||.:.|.||:||
Human   863 VVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec3	NP_648976.2	PH-EXOC1	9..126	CDD:270202	48/119 (40%)
Sec3	NP_648976.2	Sec3_C	200..866	CDD:286804	300/735 (41%)
EXOC1	XP_005265804.1	PH-EXOC1	3..120	CDD:270202	48/119 (40%)
EXOC1	XP_005265804.1	Sec3_C	184..889	CDD:370669	300/734 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141253
Domainoid	1	1.000	527	1.000	Domainoid score	I290
eggNOG	1	0.900	-	-		E1_KOG2148
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41241
Inparanoid	1	1.050	646	1.000	Inparanoid score	I805
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55676
OrthoDB	1	1.010	-	-		D201698at2759
OrthoFinder	1	1.000	-	-		FOG0005025
OrthoInspector	1	1.000	-	-		oto89322
orthoMCL	1	0.900	-	-		OOG6_102748
Panther	1	1.100	-	-	O	PTHR16092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6519
SonicParanoid	1	1.000	-	-		X4672
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800