Protein Alignment Sec3 and EXOC1

DIOPT Version :10

• Sequence 1: NP_648976.2
• Gene: Sec3 / 39940
• FlyBaseID: FBgn0266669
• Length: 889
• Species: Drosophila melanogaster
• Sequence 2: XP_005265804.1
• Gene: EXOC1 / 55763
• HGNCID: 30380
• Length: 912
• Species: Homo sapiens
• Alignment Length: 960
• Identity: 380/960 - (39%)
• Similarity: 557/960 - (58%)
• Gaps: 125/960 - (13%)

  Fly     7 MANIKHTLQKELFLASGERLLSVVTVVKK-KDKKPCYLC-VVTTAPPVPVVTLCLIKQSEQREGE 69
            |..|||.||:::|..:.|||||:|.|.|. |.||.|:|| .|||..||.|.   ::|..:..:|:
Human     1 MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVK---VVKVKKSDKGD 62

  Fly    70 -YKRKRSWQLDEIKWVDGRNEQFETHEFDLQLEKLYKWYALNPHERQNFLAVLNRQIQKSVRGQR 133
             |||:.:|.|.::..||.::...|..||||..||:|||.|.:..|:..|::.:.:..|:.:| ::
Human    63 FYKRQIAWALRDLAVVDAKDAIKENPEFDLHFEKIYKWVASSTAEKNAFISCIWKLNQRYLR-KK 126

  Fly   134 AEFRNVPAAWLSEKSP----EKVALGRAVQKTQHMDDEEDEEEEAQEFTALTDKEANELGKLFSE 194
            .:|.||.:..|.|..|    :.|..|              :||...|:..|..:|..::..:...
Human   127 IDFVNVSSQLLEESVPSGENQSVTGG--------------DEEVVDEYQELNAREEQDIEIMMEG 177

  Fly   195 CDFAIKDAEQFIEQLSRELHDLDGANMQSVLASEQKVLKMMEHIDNAISEADKFENRLDSYEDIL 259
            |::||.:||.|.|:|||||..|||||:||::|||::|..:|:.:|.|:.|.|:.|.:|.|||::|
Human   178 CEYAISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDEALKEVDQIELKLSSYEEML 242

  Fly   260 GHVKETMEKIGGKNAMIEIANNNNIKLMKELNKVISQLDLPHSQQQALDEPDLKTANGRKAAIAA 324
            ..|||.|::|...|.:|.::|.||:||:.|:..:::.:||.....:||.|.||.::.|.:|...|
Human   243 QSVKEQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHIKALQEGDLASSRGIEACTNA 307

  Fly   325 AQCLQQAMNSDIDPALLRLEAVQDQRKRFEKWKQKFSATVSRFMNNLFI--------HLGNEIGD 381
            |..|.|.||..:.|....|.||:.|::||...::.|:..::..:||:|:        .|.|....
Human   308 ADALLQCMNVALRPGHDLLLAVKQQQQRFSDLRELFARRLASHLNNVFVQQFTQALLQLYNRSYF 372

  Fly   382 MQVT-----------STELTLPNHSNVHRELTPYTELMHWTKAMDRKTYDGLMRVYTASLSKIYD 435
            :.|.           |.|||||||...||:|..|.:||.|.|:.|...|:||.:.|...||::|:
Human   373 LSVPGHDQSSTLAQHSVELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYE 437

  Fly   436 RDVRNFFNLAKI-----------------------QVTEKLRNSREDLDMSTSS----------- 466
            |::::||.:|||                       |.||.|..|...|..||||
Human   438 REIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQSSGN 502

  Fly   467 -RKSAVSTIPYGTLGINRDQWGPGVETADRMRFDALLEKVLAELEPIALQEQLFCINFF--QMDV 528
             |..:.|.:..|.:..:      .::.|||.:||.:.|:||:||||:.|.||.|...||  |...
Human   503 RRSQSSSLLDMGNMSAS------DLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQQHQ 561

  Fly   529 ISPTTKNTQTTLEMEKAVDMTQSIISGAVSPSGDGVPQKRIDRQIN-----------EDVRKLMM 582
            ..|.|        |.:|.|:....:|                ||.|           :.:|::|:
Human   562 SMPGT--------MAEAEDLDGGTLS----------------RQHNCGTPLPVSSEKDMIRQMMI 602

  Fly   583 GLFGCLEPELVSFIQSFERVDSFYSLYVFVRLTQHVMSAQ--DTHSFLSMTFASALVQVKRSFDR 645
            .:|.|:||||.:.|...:::|||.|||:.|:::.||.:||  |..||||.|..:.||.|||:||:
Human   603 KIFRCIEPELNNLIALGDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDK 667

  Fly   646 FMQNQLLSIREAKLHKRSK-AILPYVENFENFAQTAEGIFRKSDRRTDMEKWYLQLVNAIFEGIQ 709
            .:.||:..:.|.|:.|:|| .|||:|..||.||..||.||:.::||.|::|.|.:|:..:|..::
Human   668 CISNQIRQMEEVKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVE 732

  Fly   710 LHSQEHPKTPVQVVRMENYHHMYALLAQLKVPGLDALKKEAKKCYNDALKAYVTQYFGRPLEKLN 774
            ..:.|..|||..||.|||:||::|.|::||:..|:|.|||||:.|.|.|::||....|:||||||
Human   733 KVANESQKTPRDVVMMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLN 797

  Fly   775 QFFEGVQLKVAQGVKETEISYQMAFSKQELRKVIAQYPAREVKKGLENLYKKVEKHLSEEENLLQ 839
            .|||||:.:||||::|.|:|||:||:||||||||.:||.:||||||:||||||:|||.|||||||
Human   798 HFFEGVEARVAQGIREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEENLLQ 862

  Fly   840 VVWHAMQEEFIAQYNYLEERIQKCYAGAMINLEFNIQDILAFFSDIARSH 889
            ||||:||:|||.||.:.|..|.:||.|:.:.:||.|||||.:.|.||:||
Human   863 VVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH 912

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec3	NP_648976.2	PH-EXOC1	9..126	CDD:270202	48/119 (40%)
		Sec3_C	200..866	CDD:401638	300/735 (41%)
EXOC1	XP_005265804.1	PH-EXOC1	3..120	CDD:270202	48/119 (40%)
		Sec3_C	184..889	CDD:401638	300/734 (41%)