DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec3 and exoc1

DIOPT Version :9

Sequence 1:	NP_648976.2	Gene:	Sec3 / 39940	FlyBaseID:	FBgn0266669	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	XP_021324037.1	Gene:	exoc1 / 322338	ZFINID:	ZDB-GENE-030131-1057	Length:	921	Species:	Danio rerio

Alignment Length:	952	Identity:	373/952 - (39%)
Similarity:	566/952 - (59%)	Gaps:	100/952 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MANIKHTLQKELFLASGERLLSVVTVVKK-KDKKPCYLC-VVTTAPPVPVVTLCLIKQSEQREGE 69
            |..|||.||:::|..:.|||||:|.|.|. |.||.|:|| .|||..||.|.   ::|..:..:|:
Zfish     1 MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVK---VVKVKKSDKGD 62

  Fly    70 -YKRKRSWQLDEIKWVDGRNEQFETHEFDLQLEKLYKWYALNPHERQNFLAVLNRQIQKSVRGQR 133
             |||:.:|:|.::..||.::...|..||||..||:|:|.|.:..|:.:|::.:.:..|:.:| ::
Zfish    63 FYKRQMAWELRDLTEVDAKDANKENPEFDLHFEKVYRWVASSTAEKNSFISCIWKLNQRYLR-KK 126

  Fly   134 AEFRNVPAAWLSE--KSPEKVALGRAVQKTQHMDDEEDEEEEAQEFTALTDKEANELGKLFSECD 196
            .||.||....|.|  |:.|.|..|   :.......:||..::.||..|   :|..::..:...|:
Zfish   127 VEFVNVSPQLLEELPKAEESVPSG---ESQSVAGGDEDALDDYQELNA---REEQDIEGMMEVCE 185

  Fly   197 FAIKDAEQFIEQLSRELHDLDGANMQSVLASEQKVLKMMEHIDNAISEADKFENRLDSYEDILGH 261
            :||.:||.|.|:|||||..|||||:||::|||::|..:|:.:|.|::|.|..|.:|.|||::|..
Zfish   186 YAISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNTLMQLLDQALAEVDTIEGKLLSYEEMLQS 250

  Fly   262 VKETMEKIGGKNAMIEIANNNNIKLMKELNKVISQLDLPHSQQQALDEPDLKTANGRKAAIAAAQ 326
            |||.|::|...|.:|:|:|.||.||:.|:..:::.:||.....:||.|.||.:..|.:|.|.|::
Zfish   251 VKEQMDQISQSNRLIQISNTNNGKLLDEIQFLVNYMDLSKGHIKALQEGDLSSPKGIEACINASE 315

  Fly   327 CLQQAMNSDIDPALLRLEAVQDQRKRFEKWKQKFSATVSRFMNNLFIHLGNEIGDMQVT------ 385
            .|.|.||..:.|...:|.|::.|:..|.:.:..|:..::..:||:|:|..|.....::|
Zfish   316 ALSQCMNVALKPGHDKLMAIKQQQHLFSELRDTFARRLTNHLNNVFVHQFNHFSHFKMTIPQFYR 380

  Fly   386 ------------------STELTLPNHSNVHRELTPYTELMHWTKAMDRKTYDGLMRVYTASLSK 432
                              :.|||||.||.:||:|..|.:||.|.|...|:.|:||.|.|...:::
Zfish   381 SSCLSLPGHDQSSTLAQHTAELTLPKHSPLHRDLLRYAKLMEWLKNTQREKYEGLSRTYMDYMTR 445

  Fly   433 IYDRDVRNFFNLAKI------------------------QVTEKLRNSREDLDMSTSS------- 466
            :|:|::::||.:|||                        |.||.|..|...|..||||
Zfish   446 LYEREIKDFFEVAKIKMAGTSKDGKGKFATLPRKESALKQETESLHGSSGKLTGSTSSLNKLAVS 510

  Fly   467 -----RKSAVSTIPYGTLGINRDQWGPGVETADRMRFDALLEKVLAELEPIALQEQLFCINFFQM 526
                 |..:.|.:..|.:..:      .::.|||.|||.:.|:||:||||:.|.||.|...||::
Zfish   511 SSNSRRSQSSSLLDMGNMSAS------DLDVADRTRFDKIFEQVLSELEPLCLAEQDFISKFFKL 569

  Fly   527 DVISPTTKNTQTTLEMEKAVDMTQSII-SGAVSPSGDGVPQKRIDRQINEDVRKLMMGLFGCLEP 590
            ..|        .||...:.:|.:..:: |..||.....:.:|       :.||.:|..:|..:|.
Zfish   570 QQI--------PTLAQGENMDDSDGLMHSKPVSEHRHSISEK-------DMVRMMMNKIFQSIET 619

  Fly   591 ELVSFIQSFERVDSFYSLYVFVRLTQHVMSAQ--DTHSFLSMTFASALVQVKRSFDRFMQNQLLS 653
            ||.|.|...:::|||.|||:.|:::.||.:|:  |..|:||.|..:.||.|||:||:.:..|:..
Zfish   620 ELNSLIALGDKIDSFNSLYMLVKMSHHVWTAENVDPASYLSTTLGNVLVTVKRNFDKCISAQIRQ 684

  Fly   654 IREAKLHKRSK-AILPYVENFENFAQTAEGIFRKSDRRTDMEKWYLQLVNAIFEGIQLHSQEHPK 717
            :.|.|:.|:|| .|||:|..||.||:.||.|||.::||.|::|.|::|:.|:|..::..:.|..|
Zfish   685 MEEVKISKKSKVGILPFVTGFEEFAKLAEAIFRNAERRGDLDKAYIKLMRAVFNNVEKVANESQK 749

  Fly   718 TPVQVVRMENYHHMYALLAQLKVPGLDALKKEAKKCYNDALKAYVTQYFGRPLEKLNQFFEGVQL 782
            ||..||.|||:||:::.|:.||:..|:|.:||||:.|.:.|::||....|:||||||.|||||:.
Zfish   750 TPRDVVMMENFHHIFSTLSSLKISCLEAERKEAKQKYTEHLQSYVINSLGQPLEKLNHFFEGVEA 814

  Fly   783 KVAQGVKETEISYQMAFSKQELRKVIAQYPAREVKKGLENLYKKVEKHLSEEENLLQVVWHAMQE 847
            :|||||:|.|:|||:||:||||||||.:||.:||||||:|||:||:|||.:||:|||||||:||:
Zfish   815 RVAQGVREEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYRKVDKHLCDEESLLQVVWHSMQD 879

  Fly   848 EFIAQYNYLEERIQKCYAGAMINLEFNIQDILAFFSDIARSH 889
            |||.||.:.|..|.:||.|:.|.:||.|||:|.:||.||:||
Zfish   880 EFIRQYKHFEGLINRCYPGSGITMEFTIQDMLEYFSSIAQSH 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec3	NP_648976.2	PH-EXOC1	9..126	CDD:270202	47/119 (39%)
Sec3	NP_648976.2	Sec3_C	200..866	CDD:286804	290/729 (40%)
exoc1	XP_021324037.1	PH-EXOC1	3..120	CDD:270202	47/119 (39%)
exoc1	XP_021324037.1	Sec3_C	190..898	CDD:313056	290/728 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574158
Domainoid	1	1.000	522	1.000	Domainoid score	I286
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41241
Inparanoid	1	1.050	645	1.000	Inparanoid score	I787
OMA	1	1.010	-	-		QHG55676
OrthoDB	1	1.010	-	-		D201698at2759
OrthoFinder	1	1.000	-	-		FOG0005025
OrthoInspector	1	1.000	-	-		oto39410
orthoMCL	1	0.900	-	-		OOG6_102748
Panther	1	1.100	-	-	LDO	PTHR16092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4672
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870