DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec3 and Exoc1

DIOPT Version :9

Sequence 1:	NP_648976.2	Gene:	Sec3 / 39940	FlyBaseID:	FBgn0266669	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	XP_038947805.1	Gene:	Exoc1 / 305287	RGDID:	1304939	Length:	919	Species:	Rattus norvegicus

Alignment Length:	945	Identity:	374/945 - (39%)
Similarity:	567/945 - (60%)	Gaps:	88/945 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MANIKHTLQKELFLASGERLLSVVTVVKK-KDKKPCYLC-VVTTAPPVPVVTLCLIKQSEQREGE 69
            |..|||.||:::|..:.|||||:|.|.|. |.||.|:|| .|||..||.|.   ::|..:..:|:
  Rat     1 MTAIKHALQRDIFTPNDERLLSIVNVCKAGKKKKNCFLCATVTTERPVQVK---VVKVKKSDKGD 62

  Fly    70 -YKRKRSWQLDEIKWVDGRNEQFETHEFDLQLEKLYKWYALNPHERQNFLAVLNRQIQKSVRGQR 133
             |||:.:|.|.::..||.::...|:.||||..:|:|:|.|.:..|:..|::...:..|:.:| ::
  Rat    63 FYKRQIAWALRDLAVVDAKDAIKESPEFDLHFDKVYRWVASSIAEKNAFISCTWKLNQRYLR-KK 126

  Fly   134 AEFRNVPAAWLSEKSPEKVALGRAVQKTQHMDDEEDEEEEAQEFTALTDKEANELGKLFSECDFA 198
            .:|.|| ::.|.|:.| ||| ..:|...::......:||...|:..|..:|..::..:...|:.|
  Rat   127 IDFLNV-SSQLLEELP-KVA-EESVPSGENQSVAGGDEEAVDEYQELNAREEQDIEIMMEGCECA 188

  Fly   199 IKDAEQFIEQLSRELHDLDGANMQSVLASEQKVLKMMEHIDNAISEADKFENRLDSYEDILGHVK 263
            |.:||.|.|:|||||..|||||:||::|||::|..:|:.:|.|:.|.|:.|.:|.|||::|..||
  Rat   189 ISNAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMQLLDEALQEVDQIELKLSSYEEMLQSVK 253

  Fly   264 ETMEKIGGKNAMIEIANNNNIKLMKELNKVISQLDLPHSQQQALDEPDLKTANGRKAAIAAAQCL 328
            |.|::|...|.:|.::|.||:||:.|:..:::.:||.....:||.:.||.::.|.:|...||..|
  Rat   254 EQMDQISESNHLIHLSNTNNVKLLSEIEFLVNHMDLAKGHVKALQDGDLASSRGIEACTNAADAL 318

  Fly   329 QQAMNSDIDPALLRLEAVQDQRKRFEKWKQKFSATVSRFMNNLFI-------------------- 373
            .|.||..:.|....|.|::.|::||.:.::.|:..::..:||:|:
  Rat   319 LQCMNVALRPGHDMLLAIRQQQQRFSELREHFARRLASHLNNVFVQQFTQALLQLYSRSYFLSVP 383

  Fly   374 -HLGNEIGDMQVTSTELTLPNHSNVHRELTPYTELMHWTKAMDRKTYDGLMRVYTASLSKIYDRD 437
             |  ::...:...|.|||||||...||:|..|.:||.|.|:.|...|:||.:.|...||::|:|:
  Rat   384 GH--DQSSTLAQHSAELTLPNHHPFHRDLLRYAKLMEWLKSTDYGKYEGLTKNYMDYLSRLYERE 446

  Fly   438 VRNFFNLAKI-----------------------QVTEKLRNSREDLDMSTSS------------R 467
            :::||.:||:                       |.||.|..|...|..||||            |
  Rat   447 IKDFFEVAKMKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQSSGSRR 511

  Fly   468 KSAVSTIPYGTLGINRDQWGPGVETADRMRFDALLEKVLAELEPIALQEQLFCINFFQMDVISPT 532
            ..:.|.:..|.:..:      .::.|||.:||.:.|:||:||||:.|.||.|...||::.
  Rat   512 SQSSSLLDMGNMSAS------DLDVADRTKFDKIFEQVLSELEPLCLAEQDFISKFFKLQ----- 565

  Fly   533 TKNTQTTLEMEKAVDMTQSIISGAVSPSGDGVPQKRIDRQINEDVRKLMMGLFGCLEPELVSFIQ 597
             ::...:..|.:|.|:....:|...| ||..:|..    ...:.:|::|:.:|.|:||||.:.|.
  Rat   566 -QHQNLSASMAEAEDLDGGSLSRPQS-SGSLLPVS----SEKDMIRQMMIKIFRCIEPELNNLIA 624

  Fly   598 SFERVDSFYSLYVFVRLTQHVMSAQ--DTHSFLSMTFASALVQVKRSFDRFMQNQLLSIREAKLH 660
            ..::||||.|||:.|:::.||.:||  |..||||.|..:.||.|||:||:.:.||:..:.|.|:.
  Rat   625 LGDKVDSFNSLYMLVKMSHHVWTAQNVDPASFLSTTLGNVLVTVKRNFDKCISNQIRQMEEVKIS 689

  Fly   661 KRSK-AILPYVENFENFAQTAEGIFRKSDRRTDMEKWYLQLVNAIFEGIQLHSQEHPKTPVQVVR 724
            |:|| .|||:|..||.||..||.||:.::||.|::|.|.:|:..:|..::..:.|..|||..||.
  Rat   690 KKSKVGILPFVAEFEEFAGLAESIFKSAERRGDLDKAYTKLIRGVFINVEKVANESQKTPRDVVM 754

  Fly   725 MENYHHMYALLAQLKVPGLDALKKEAKKCYNDALKAYVTQYFGRPLEKLNQFFEGVQLKVAQGVK 789
            |||:||::|.|::||:..|:|.|||||:.|.|.|::||....|:||||||.|||||:.:||||::
  Rat   755 MENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSLGQPLEKLNHFFEGVEARVAQGIR 819

  Fly   790 ETEISYQMAFSKQELRKVIAQYPAREVKKGLENLYKKVEKHLSEEENLLQVVWHAMQEEFIAQYN 854
            |.|:|||:||:||||||||.:||.:||||||:||||||:|||.|||||||||||:||:|||.||.
  Rat   820 EEEVSYQLAFNKQELRKVIKEYPGKEVKKGLDNLYKKVDKHLCEEENLLQVVWHSMQDEFIRQYK 884

  Fly   855 YLEERIQKCYAGAMINLEFNIQDILAFFSDIARSH 889
            :.|..|.:||.|:.:.:||.|||||.:.|.||:||
  Rat   885 HFEGLIARCYPGSGVTMEFTIQDILDYCSSIAQSH 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec3	NP_648976.2	PH-EXOC1	9..126	CDD:270202	46/119 (39%)
Sec3	NP_648976.2	Sec3_C	200..866	CDD:286804	294/724 (41%)
Exoc1	XP_038947805.1	PH-EXOC1	3..120	CDD:270202	46/119 (39%)
Exoc1	XP_038947805.1	Sec3_C	191..896	CDD:401638	294/723 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334919
Domainoid	1	1.000	532	1.000	Domainoid score	I273
eggNOG	1	0.900	-	-		E1_KOG2148
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	562	1.000	Inparanoid score	I1051
OMA	1	1.010	-	-		QHG55676
OrthoDB	1	1.010	-	-		D201698at2759
OrthoFinder	1	1.000	-	-		FOG0005025
OrthoInspector	1	1.000	-	-		oto96447
orthoMCL	1	0.900	-	-		OOG6_102748
Panther	1	1.100	-	-	O	PTHR16092
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4672
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810