DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sec3 and SPAC17G8.12

DIOPT Version :9

Sequence 1:	NP_648976.2	Gene:	Sec3 / 39940	FlyBaseID:	FBgn0266669	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_593735.1	Gene:	SPAC17G8.12 / 2542129	PomBaseID:	SPAC17G8.12	Length:	608	Species:	Schizosaccharomyces pombe

Alignment Length:	472	Identity:	91/472 - (19%)
Similarity:	169/472 - (35%)	Gaps:	142/472 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 NRQIQK--SVRGQRAEFRNVPAAWLSEKSPE-------KVALGRAVQKTQHMDDEEDEEEEAQEF 177
            :|..:|  ||..:|....|.|::.:|..:|.       :::...|:.:|.  .|.:|:    ..|
pombe   225 SRSAKKKLSVEKERRFSDNKPSSNVSRGTPSSAHSDVIEISSSSAIARTS--GDRKDD----VLF 283

  Fly   178 TALTDKEANELGKLFSECDFAIKDAEQFIEQLSRELHDLDGANMQSVLASEQKVLKMMEHIDNAI 242
            ...|.:..|:..::|.:     :.|:.|..:.|          ::.....||     ....::..
pombe   284 DTSTQRRDNQTREMFIQ-----EQAQLFPSKPS----------LRKTTRREQ-----APSFNSGT 328

  Fly   243 SEADKFENRLD-SYEDILGHVKETMEKI-GGKNAMIEIANNNNIKLMKELN-----KVISQLDLP 300
            |.:::.:|.:. |||      |.|...: .||..|    :..::||...|.     ...|::|..
pombe   329 SSSERGKNSISGSYE------KNTALALEAGKYNM----SQKDVKLSSSLESNTFASDFSKVDRD 383

  Fly   301 HSQ---QQALDEPDLKTANGRKAAIAAAQCLQQAMNSDIDPALLRLEAVQDQRKRFEKWKQKFSA 362
            .:|   ..:|:.|.:.|::.:.::.:.......:......||:.:|......|      :....|
pombe   384 ATQAALSSSLETPSVLTSSYKPSSSSKVSAKSVSRKPTGAPAIPKLPPKHPSR------QPTVRA 442

  Fly   363 TVSRFMNNLFIHLGNEIGDMQVTSTELTLPN-HSNVHRELTPYTELMHW------TKAMDRKTYD 420
            |.|                   |..::..|| ..::..||.|..|.:.:      :|...:||..
pombe   443 TPS-------------------TGKQIEPPNDEPSIGNELLPLFESLRFENRKTTSKPKAKKTLV 488

  Fly   421 GLM--RVYTASLSKIYDRDVRNFFNLAKIQVTEKLRNSREDLDMSTSSRKSAVSTIPYGTLGINR 483
            ..:  :.:.||:.|:||                  .||:.:|........|.:||:
pombe   489 TSIPTKPHQASVEKVYD------------------LNSKINLKNIPEQSISRLSTL--------- 526

  Fly   484 DQWGPGVETADRMR-----FD-ALLEKV--LAELEPIALQE--------QLFC------INFFQM 526
             :|..|....|.::     || |::..|  ||| |.|.||.        .|.|      ||.|.:
pombe   527 -KWNEGTTIKDVLKQTEFSFDGAIISSVENLAE-EEIELQNIKSQLQDCALGCESINSTINLFSL 589

  Fly   527 DVISPTTKNTQTTLEME 543
            ::  .|..|....:|.:
pombe   590 EL--STALNGVINIEQQ 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec3	NP_648976.2	PH-EXOC1	9..126	CDD:270202	1/3 (33%)
Sec3	NP_648976.2	Sec3_C	200..866	CDD:286804	74/385 (19%)
SPAC17G8.12	NP_593735.1	Sec3-PIP2_bind	52..131	CDD:291926
SPAC17G8.12	NP_593735.1	Sec3_C_2	520..605	CDD:259411	25/98 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000