DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sec3 and sec-3

DIOPT Version :9

Sequence 1:	NP_648976.2	Gene:	Sec3 / 39940	FlyBaseID:	FBgn0266669	Length:	889	Species:	Drosophila melanogaster
Sequence 2:	NP_508530.1	Gene:	sec-3 / 180598	WormBaseID:	WBGene00018703	Length:	848	Species:	Caenorhabditis elegans

Alignment Length:	909	Identity:	279/909 - (30%)
Similarity:	466/909 - (51%)	Gaps:	87/909 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 MANIKHTLQKELFLASGERLLSVVTVVK---KKDKKPCYLCVVTTAPPVPVVTLCLIKQSEQREG 68
            |:.|:..:|::||....||:.::|.|.|   ||.|....||:..|......|.|..:|  .:::.
Worm     1 MSAIRKIIQRQLFQKDDERIQAIVNVSKLDGKKKKNQTLLCLAVTIEHPIAVRLYFVK--GEKDD 63

  Fly    69 EYKRKRSWQLDEIKWVDGRNEQFETHEFDLQL-EKLYKWYALNPHERQNFLAVLNRQIQKSVRGQ 132
            .:|:|..:.|.|::.:||.|.:..:.||.:.: :..|...|.:..|:..|:    |::.|
Worm    64 TFKKKDRFNLREVREIDGINPKKASPEFHITIGDHQYVILAGSAEEKDEFI----RELYK----- 119

  Fly   133 RAEFRNVPAAWLSEKSPE--KVALGRAVQKTQHMDDEEDEEEEA--QEFTALTDKEANELGKLFS 193
                  :...:|..:.|:  ..:|.:...:|..:..|..|.:.|  .::..:::||..:..||.:
Worm   120 ------LSCQYLPVQMPDFCNFSLPQLESETSIIPIELPEHDMAMQSDYQPISNKEDADFRKLIA 178

  Fly   194 ECDFAIKDAEQFIEQLSRELHDLDGANMQSVLASEQKVLKMMEHIDNAISEADKFENRLDSYEDI 258
            ..:..|.:|..|.|.|:.:|..|||||:.|::.||..|.:::..||.|::..:..|..||..:||
Worm   179 RANLTIGEAHIFAEMLTEQLQSLDGANINSMMDSENSVNQLLSSIDAALTGVESVEKELDRCDDI 243

  Fly   259 LGHVKETMEKIGGKNAMIEIANNNNIKLMKELNKVISQLD-LPHSQQQALDEPDLKTANGRKAAI 322
            |..|:.::|.|..|:::..:...|..:|.:|:...::.|. :..|..:.|.:.:.......:...
Worm   244 LAFVRNSIELIEEKDSLSVVERKNKQRLNEEIVSFVNSLQAVTDSHIETLKQANFSNPESVQRCT 308

  Fly   323 AAAQCLQQAMNSDIDPALLRLEAVQDQRKRFEKWKQKFSATVSRFMNNLFIHLG---NEIGDMQV 384
            .||:.:.|..:..|...:|:::|.||:....        ..|..|::.|..||.   :.:.|:.:
Worm   309 DAARAVAQFWHGRISKPMLQMKAYQDRNDEL--------TAVDVFVDRLMSHLSALFSNLNDLSL 365

  Fly   385 TST--ELTLPNHSNVHRELTPYTELMHWTKAMDRKTYDGLMRVYTASLSKIYDRDVRNFF----- 442
            ...  ||.:|..|...|.|:|.::|::|.|....|..:.:::.|..|.:.:|.|...|||
Worm   366 DHEWHELCIPKQSQRFRALSPLSDLINWLKTNRPKACNLVLQKYIDSTNLLYKRLFDNFFETLIN 430

  Fly   443 NLAKIQVTEKLRNSREDLDMS-TSSRKSAVSTIPYGTLGINRDQWGPGVETADRMRFDALLEKVL 506
            .:.|...:||...:.|..::| .|..:|.:||                ....|......|:|.||
Worm   431 KVPKANSSEKKSKANESANISLRSDNQSFLST----------------SSEIDTEVLPQLIETVL 479

  Fly   507 AELEPIALQEQLFCINFFQMDVISPTTKNTQTTLEMEKAVDMTQSIISGAVSPSGDGVPQKRIDR 571
            |||..:...||.|.:.||.:        |::...:.:     |.|..||..|..|.    :.:::
Worm   480 AELSAVIDAEQKFVVRFFHI--------NSELLAQFD-----TTSTGSGDSSSLGG----RSMEK 527

  Fly   572 QINEDVRKLMMGLFGCLEPELVSFIQSFERVDSFYSLYVFVRLTQHVMSAQDTHSFLSMTFASAL 636
            .:||.||.:|..||..|...|.||.::..|.:....|.:||.:::.|:..||..|:.|:||.|.:
Worm   528 HMNEQVRHVMGNLFDSLNIHLDSFCRAVCRHNPSNVLLLFVIMSKKVLLPQDPSSYFSITFGSLV 592

  Fly   637 VQVKRSFDRFMQNQLLSIREAKLHKRSK-AILPYVENFENFAQTAEGIFRKSDRRTDMEKWYLQL 700
            |.:||.||.|:|.:.....|.::.|::: .|||.:..|.||.:.||.||..::||||:||.|..|
Worm   593 VLIKRQFDAFIQMECSQYSEVRIAKKTRIGILPSIFRFANFVRRAEIIFENAERRTDLEKAYFNL 657

  Fly   701 VNAIFEGIQ-LHSQEHPKTPVQVVRMENYHHMYALLAQLKVPGLDALKKEAKKCYNDALKAYVTQ 764
            ..|:.:||| ..:.::.|:|..||:.||||.:|..|::||:..||..:|:||....:.:.|||.:
Worm   658 CRAVCDGIQKAAANQYSKSPSSVVKFENYHELYLTLSELKISCLDQQRKDAKALKEEHIDAYVKE 722

  Fly   765 YFGRPLEKLNQFFEGVQLKV-AQGVKETEISYQMAFSKQELRKVIAQYPAREVKKGLENLYKKVE 828
            :.||||:::..||:.|...: .:|::..|||||..||:.||:|||:|:|.:|||||||.||||:|
Worm   723 FMGRPLKEIQTFFDNVNNFIETRGIRPDEISYQQQFSRIELKKVISQHPGKEVKKGLEQLYKKIE 787

  Fly   829 KHLSEEENLLQVVWHAMQEEF---IAQYNYLEERIQKCYAGAMINLEFNIQDILAFFSDIARSH 889
            |:|....:||||||..|||:|   ||:||.|   |..||.|:.|.||.:...:|.|||:||:.|
Worm   788 KNLVANSSLLQVVWRDMQEQFVKQIAEYNKL---ILTCYPGSKIELEVSTDTVLQFFSEIAQQH 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sec3	NP_648976.2	PH-EXOC1	9..126	CDD:270202	32/120 (27%)
Sec3	NP_648976.2	Sec3_C	200..866	CDD:286804	222/683 (33%)
sec-3	NP_508530.1	PH-EXOC1	3..122	CDD:270202	33/135 (24%)
sec-3	NP_508530.1	Sec3_C	186..825	CDD:303102	222/682 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158206
Domainoid	1	1.000	330	1.000	Domainoid score	I619
eggNOG	1	0.900	-	-		E1_KOG2148
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41241
Inparanoid	1	1.050	394	1.000	Inparanoid score	I1125
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55676
OrthoDB	1	1.010	-	-		D201698at2759
OrthoFinder	1	1.000	-	-		FOG0005025
OrthoInspector	1	1.000	-	-		oto19849
orthoMCL	1	0.900	-	-		OOG6_102748
Panther	1	1.100	-	-	LDO	PTHR16092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6519
SonicParanoid	1	1.000	-	-		X4672
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800