Protein Alignment Sec3 and Sec3

DIOPT Version :10

• Sequence 1: NP_648976.2
• Gene: Sec3 / 39940
• FlyBaseID: FBgn0266669
• Length: 889
• Species: Drosophila melanogaster
• Sequence 2: XP_551765.4
• Gene: Sec3 / 1280298
• VectorBaseID: AGAMI1_009139
• Length: 890
• Species: Anopheles gambiae
• Alignment Length: 901
• Identity: 555/901 - (61%)
• Similarity: 681/901 - (75%)
• Gaps: 32/901 - (3%)

  Fly     8 ANIKHTLQKELFLASGERLLSVVTVVK-KKDKKPCYLCVVTTAPPVPVVTLCLIKQSEQREGEYK 71
            |.||:..|||||.|..||:|||..|.| .|.||..|||:|:|..|..:|::|.|||.:  :..||
Mosquito     3 AGIKYIFQKELFDALDERILSVCNVSKLHKRKKTSYLCIVSTIKPSVIVSVCQIKQYD--KAVYK 65

  Fly    72 RKRSWQLDEIKWVDGRNEQFETHEFDLQLEKLYKWYALNPHERQNFLAVLNRQIQKSVR-GQRAE 135
            :||||.|:|||.||||||..:||:||:.|:|.|:|:|.|.||||||:.||.:||.|... |::|.
Mosquito    66 KKRSWSLEEIKCVDGRNEATDTHDFDMLLDKPYRWFAANLHERQNFITVLWKQIHKHCTVGEKAV 130

  Fly   136 FRNVPAAWLSEKSPEKVA------LGRAVQKTQHMDDEEDEEE--EAQEFTALTDKEANELGKLF 192
            |:|:|..|||||||||..      .|.||..     |:|||.|  |.::|.||||||...|.||.
Mosquito   131 FKNIPKQWLSEKSPEKQIDEKYPNHGGAVSA-----DDEDEIEGFENEDFHALTDKEEAHLSKLV 190

  Fly   193 SECDFAIKDAEQFIEQLSRELHDLDGANMQSVLASEQKVLKMMEHIDNAISEADKFENRLDSYED 257
            :|||:||.:||.|::.||..|..|||||:||||.||::|..:||.|:.||.||:|.|.|||.|::
Mosquito   191 AECDYAISNAELFMDDLSHNLLQLDGANIQSVLESEKQVQMLMERIEEAIKEAEKVEKRLDDYDE 255

  Fly   258 ILGHVKETMEKIGGKNAMIEIANNNNIKLMKELNKVISQLDLPHSQQQALDEPDLKTANGRKAAI 322
            ||.||::||||:|.||.||||||.||::|:.||.||::||||||..|.||.:.|| |..|..|||
Mosquito   256 ILCHVRDTMEKMGEKNQMIEIANTNNVRLLLELEKVVTQLDLPHVHQLALTDTDL-TPKGLPAAI 319

  Fly   323 AAAQCLQQAMNSDIDPALLRLEAVQDQRKRFEKWKQKFSATVSRFMNNLFIHLGNEIGDMQVTST 387
            ||.:.||.|||||||||||||.|||||||||||||.|||.|:||.:||||||||| :||.|...|
Mosquito   320 AAGKALQMAMNSDIDPALLRLTAVQDQRKRFEKWKAKFSQTISRHLNNLFIHLGN-LGDSQTPFT 383

  Fly   388 -ELTLPNHSNVHRELTPYTELMHWTKAMDRKTYDGLMRVYTASLSKIYDRDVRNFFNLAKIQVTE 451
             ||:||.|.|||:||..:.|||||.|.||||.||.|::||||||||:||||::.||..||..:|.
Mosquito   384 NELSLPKHQNVHKELCTFMELMHWMKTMDRKAYDALIKVYTASLSKVYDRDIQIFFENAKQALTL 448

  Fly   452 KLRNSREDLDMSTSSRKSAVS-------TIPYGTLGINRDQWGPGVETADRMRFDALLEKVLAEL 509
            |..:||||::.|:.|.|..:.       ..|||.||.:::.|.||.|..:|.|||::||||||||
Mosquito   449 KQFSSREDINNSSISNKLKLGPQSNKQPAQPYGILGTSKEMWSPGAEAIERQRFDSILEKVLAEL 513

  Fly   510 EPIALQEQLFCINFFQMDVISPTTKNTQTTLEMEKAVDMTQSIISGAVSPSGDGVPQKRIDRQIN 574
            ||:||.||.|||.|||:||||||.|||||||:...    .:::.......:...:||:|:|||||
Mosquito   514 EPVALSEQHFCIAFFQLDVISPTAKNTQTTLDAAS----NETVNQKDERDTAPHIPQRRLDRQIN 574

  Fly   575 EDVRKLMMGLFGCLEPELVSFIQSFERVDSFYSLYVFVRLTQHVMSAQDTHSFLSMTFASALVQV 639
            ||||::|..||..||.|:.:||.|||::|::|||||.||||||||||||..|||||||||||:.|
Mosquito   575 EDVRRMMGELFANLETEINNFILSFEKLDNYYSLYVLVRLTQHVMSAQDAQSFLSMTFASALIHV 639

  Fly   640 KRSFDRFMQNQLLSIREAKLHKRSK-AILPYVENFENFAQTAEGIFRKSDRRTDMEKWYLQLVNA 703
            |||||:|||:||.||.|:||.|||| .:||||||||.||.|||.||:|::||.|::||||:||.|
Mosquito   640 KRSFDKFMQSQLQSIDESKLPKRSKCGLLPYVENFEEFAVTAENIFKKTERRNDLDKWYLKLVEA 704

  Fly   704 IFEGIQLHSQEHPKTPVQVVRMENYHHMYALLAQLKVPGLDALKKEAKKCYNDALKAYVTQYFGR 768
            |||.|.:|:.||.|||.|||:|||||.|::.|:|||:|.|::|:||||..||||.|||||:||||
Mosquito   705 IFERIPVHAAEHSKTPHQVVKMENYHRMHSTLSQLKIPVLESLRKEAKTRYNDAQKAYVTKYFGR 769

  Fly   769 PLEKLNQFFEGVQLKVAQGVKETEISYQMAFSKQELRKVIAQYPAREVKKGLENLYKKVEKHLSE 833
            |||:|||||||:|::|.||||:||||||||:|||||||||:.|||||||||||.|||||||||.|
Mosquito   770 PLERLNQFFEGIQVRVQQGVKDTEISYQMAYSKQELRKVISLYPAREVKKGLEQLYKKVEKHLCE 834

  Fly   834 EENLLQVVWHAMQEEFIAQYNYLEERIQKCYAGAMINLEFNIQDILAFFSDIARSH 889
            |||||||||.|||:|||.|||.||:.||:||||:||.|||.|.|:|.|||:||:||
Mosquito   835 EENLLQVVWRAMQQEFINQYNSLEQWIQRCYAGSMITLEFTINDLLDFFSEIAQSH 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sec3	NP_648976.2	PH-EXOC1	9..126	CDD:270202	64/117 (55%)
		Sec3_C	200..866	CDD:401638	433/674 (64%)
Sec3	XP_551765.4	None