DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment blot and slc6a3

DIOPT Version :9

Sequence 1:	NP_524125.2	Gene:	blot / 39939	FlyBaseID:	FBgn0027660	Length:	976	Species:	Drosophila melanogaster
Sequence 2:	NP_571830.1	Gene:	slc6a3 / 80787	ZFINID:	ZDB-GENE-010316-1	Length:	629	Species:	Danio rerio

Alignment Length:	714	Identity:	146/714 - (20%)
Similarity:	256/714 - (35%)	Gaps:	199/714 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 PTVTPSPQTTRSCISTVSSVVDSGGGRTTATSGRISSSGIVTLSDSNN---TLSEIQG-GYHDMD 177
            |.||.:...|.:.:|:||....:.|.|...         :|.:.:.|.   |.|.::. |.|...
Zfish     8 PAVTHTRTRTHTHMSSVSGSSSAAGPREVE---------LVLVKEQNGVQFTSSSLRNPGAHSHT 63

  Fly   178 HDAVSKNFSISASAHNITTASNAKLLPAVEDESNKQTKCSVFRGLVLCLCLNLSYANVVRFPREL 242
            |            .|..|..|.          ..::|.......|:..:...:..|||.|||
Zfish    64 H------------THTHTHPSG----------QQRETWGKKIDFLLSVIGFAVDLANVWRFP--- 103

  Fly   243 DRY------GSAYLVPYVVLLFLVGLPMVLLEISVGQFLGQGAAHTWRASPIFKG----ACMISR 297
              |      |.|:||||::.:.:.|:|:..:|:::||:..:|||..|:..|||||    ..:||.
Zfish   104 --YLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQYNREGAAGVWKICPIFKGVGFTVILISL 166

  Fly   298 F-ASWLSAI--WVSLQAVLALAYIGMFASNDLPF---------RECAGPVKLRLSG--------- 341
            : .|:.:.|  |       ||.|:....|.:||:         ..|:.|....|:.
Zfish   167 YVGSYYNVIIAW-------ALFYLFSSFSGELPWIHCNNTWNSPNCSDPNATLLNDTYKTTPALE 224

  Fly   342 YLLTG------TSGQE-----------CLQLTFLTPFWRNPLYF----GLLAAGLIGLWIV---- 381
            |...|      :||.:           ||.:..:.      |||    |:..:|.: :||.
Zfish   225 YFERGVLHVHESSGIDDLGAPRWQLTACLAVVIVV------LYFSLWKGVKTSGKV-VWITATMP 282

  Fly   382 -VMLCTHNAKILRRSIFVFGLV-GLVLLCTLTGWEVRNSFSRHYFPELWGFDSNLLAESNIWFNA 444
             |:|..    :|.|.:.:.|.: |:....::       .|.|.|             ::.:|..|
Zfish   283 YVVLTV----LLLRGVTLPGAIDGIKAYLSV-------DFLRLY-------------DAQVWIEA 323

  Fly   445 LMQVLFSVNCGFGALPMITGKFLYKGDAVRTSVVYLCFNLLINAIAVTLFMVQFDL-SSNGFQNM 508
            ..|:.||:..|||.|...:....:..:..|.:::....|      ::|.|...|.: |..|:.:.
Zfish   324 ATQICFSLGVGFGVLIAFSSYNKFSNNCYRDAIITSSIN------SLTSFFSGFVIFSFLGYMSQ 382

  Fly   509 EELKPLTAIYDRVLNGSREGDS-------HLLQHLVPSLIYALII------------LSAMVSIT 554
            :.    ....|:|   :.:|..       ..:..|..|.::|:|.            :..|.|:.
Zfish   383 KH----NVALDKV---ATDGPGLVFIIYPEAIATLPGSSVWAVIFFIMLLTLGIDSAMGGMESVI 440

  Fly   555 VAVYTSTRLVPR-RPNYVICLI--GLVVAVISFAAPKFLIARVLDSRLVGTMVVTALVFELIAIT 616
            ..:....:.:.: |..:.:.::  ..::::|........:..:||....||.::..::.|.|.|.
Zfish   441 TGLIDEFKFLHKHRELFTLFIVVSTFLISLICVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGIA 505

  Fly   617 WIYGAKNIYTDLEFSIGRPIFRVWMWLW-VICPAILTGILVWWCADDDQYDLLAEYLPRWAPILF 680
            |.||......|:|..||:.....|...| .:.|..|..::|...|..:.....:.|.|.||
Zfish   506 WFYGVDRFSDDIEEMIGQRPGLYWRLCWKFVSPCFLLFMVVVSFATFNPPKYGSYYFPTWA---- 566

  Fly   681 VLAVIVIIACVQIFRQVE---YNFF------GMIC---------EASKPAKEWGPADPLARHSW 726
                .::..|:.|...:.   |.|:      |..|         |......|.|.......|.|
Zfish   567 ----TMVGWCLSISSMIMVPLYAFYKFCSLPGSFCDKLAYAITPETDHHLVERGEVRQFTLHHW 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
blot	NP_524125.2	SLC5-6-like_sbd	219..659	CDD:271356	110/521 (21%)
slc6a3	NP_571830.1	SLC6sbd_DAT1	76..623	CDD:212083	125/610 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900